Antioxidant neuroprotective use of, and method of treatment using, hydroxycarbazole compounds

A method of treatment for neuroprotection in mammals comprising internally administering to a mammal in need thereof an effective amount of a compound selected from the group consisting essentially of compounds of Formula I:

• 5
• wherein:
• R7-R13 are independently —H or —OH;
• and
• A=is independently H, —OH or a moiety of Formula II:
• 6
• wherein:
• R1 is hydrogen, lower alkanoyl of up to 6 carbon atoms or aroyl selected from benzoyl and naphthoyl;
• R2 is hydrogen, lower alkyl of up to 6 carbon atoms or arylalkyl selected from benzyl, phenylethyl and phenylpropyl;
• R3 is hydrogen or lower alkyl of up to 6 carbon atoms;
• R4 is hydrogen or lower alkyl of up to 6 carbon atoms, or when X is oxygen, R4 together with R5 can represent —CH2—O—;
• X is a valency bond, —CH2, oxygen or sulfur,
• Ar is selected from phenyl, naphthyl, indanyl and tetrahydronaphthyl;
• R5 and R6 are individually selected from hydrogen, fluorine, chlorine, bromine, hydroxyl, lower alkyl of up to 6 carbon atoms, a —CONH2— group, lower alkoxy of up to 6 carbon atoms, benzyloxy, lower alkylthio of up to 6 carbon atoms, lower alkysulphinyl of up to 6 carbon atoms and lower alkylsulphonyl of up to 6 carbon atoms;
• or
• R5 and R6 together represent methylenedioxy;
• and pharmaceutically acceptable salts thereof.

A use of a compound selected from the group consisting essentially of compounds of Formula I:

• 7
• wherein:
• R7-R13 are independently —H or —OH;
• and
• A=is independently H, —OH, or a moiety of Formula II:
• 8
• wherein:
• R1 is hydrogen, lower alkanoyl of up to 6 carbon atoms or aroyl selected from benzoyl and naphthoyl;
• R2 is hydrogen, lower alkyl of up to 6 carbon atoms or arylalkyl selected from benzyl, phenylethyl and phenylpropyl;
• R3 is hydrogen or lower alkyl of up to 6 carbon atoms;
• R4 is hydrogen or lower alkyl of up to 6 carbon atoms, or when X is oxygen, R4 together with R5 can represent —CH2—O—;
• X is a valency bond, —CH2, oxygen or sulfur;
• Ar is selected from phenyl, naphthyl, indanyl and tetrahydronaphthyl;
• R5 and R6 are individually selected from hydrogen, fluorine, chlorine, bromine, hydroxyl, lower alkyl of up to 6 carbon atoms, a —CONH2— group, lower alkoxy of up to 6 carbon atoms, benzyloxy, lower alkylthio of up to 6 carbon atoms, lower alkysulphinyl of up to 6 carbon atoms and lower alkylsulphonyl of up to 6 carbon atoms;
• or
• R5 and R6 together represent methylenedioxy;
• or a pharmaceutically acceptable salt thereof, for prevention of oxidative tissue damage to organs in mammals afflicted with disease-induced ischemic trauma.

A use of a compound selected from the group consisting essentially of compounds of Formula I:

• 9
• wherein:
• R7-R13 are independently —H or —OH;
• and
• A=is independently H, —OH or a moiety of Formula II:
• 10
• wherein:
• R1 is hydrogen, lower alkanoyl of up to 6 carbon atoms or aroyl selected from benzoyl and naphthoyl;
• R2 is hydrogen, lower alkyl of up to 6 carbon atoms or arylalkyl selected from benzyl, phenylethyl and phenylpropyl;
• R3 is hydrogen or lower alkyl of up to 6 carbon atoms;
• R4 is hydrogen or lower alkyl of up to 6 carbon atoms, or when X is oxygen, R4 together with R5 can represent —CH2—O—;
• X is a valency bond, —CH2, oxygen or sulfur;
• Ar is selected from phenyl, naphthyl, indanyl and tetrahydronaphthyl;
• R5 and R6 are individually selected from hydrogen, fluorine, chlorine, bromine, hydroxyl, lower alkyl of up to 6 carbon atoms, a —CONH2— group, lower alkoxy of up to 6 carbon atoms, benzyloxy, lower alkylthio of up to 6 carbon atoms, lower alkysulphinyl of up to 6 carbon atoms and lower alkylsulphonyl of up to 6 carbon atoms;
• or
• R5 and R6 together represent methylenedioxy;
• or a pharmaceutically acceptable salt thereof, for neuroprotection in mammals.