Methods and compositions for treating and preventing mucositis
OwnerStephen T. Sonis, Edward G. Feyinventors
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Abstract
A method of reducing or inhibiting mucositis in a patient, which includes administering an inflammatory cytokine inhibitor or a mast cell inhibitor, or a combination thereof, is disclosed
Claims34
A method of treating, inhibiting, or preventing mucositis in a human patient, said method comprising administering to said patient first and second different therapeutic agents, wherein said first therapeutic agent is an NSAID, an inflammatory cytokine inhibitor, or a mast cell inhibitor;
- and said second therapeutic agent is an inflammatory cytokine inhibitor, a mast cell inhibitor, an MMP inhibitor, an NSAID, or an NO inhibitor.
A method of treating, inhibiting, or preventing mucositis in a human patient, said method comprising administering to said patient an effective amount of a therapeutic agent selected from an MMP inhibitor, an inflammatory cytokine inhibitor and a mast cell inhibitor.
A pharmaceutical composition for treating oral mucositis comprising
- (a) a first therapeutic agent comprising an NSAID, an inflammatory cytokine inhibitor, or a mast cell inhibitor;
- (b) a second, different therapeutic agent comprising an inflammatory cytokine inhibitor, a mast cell inhibitor, an MMP inhibitor, an NSAID, or an NO inhibitor;
- and
- (c) a pharmaceutically acceptable carrier, wherein said first and second therapeutic agents are present in amounts sufficient to inhibit mucositis in a patient suffering from mucositis or at risk for mucositis.
Dependencies are inferred from the claim text.