Pharmaceutical composition comprising L- carnitine or alkanoyl L-carnitine for the prevention and treatment of diseases brought about by lipid metabolism disorders
AssigneeSigma-Tau Industrie Parmaceutiche Riunite S.p.A.
InventorCavazza Claudio
Life of this patent
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Abstract
A pharmaceutical compositions comprising L-carnitine or alkanoyl L-carnitine and hydroxycitric or pantothenic acid or derivatives thereof for the prevention and treatment of diseases brought about by lipid metabolism disorders, is disclosed.
Claims10
An orally, parenterally, rectally or transdermally administrable pharmaceutical composition for treating cardiovascular, thromboembolic, atherosclerotic, hyperlipidemic disorders and obesity and for decreasing appetite, comprising L-carnitine or an alkanoyl L-carnitine wherein the alkanoyl group is a straight or branched alkanoyl having 2-8, preferably 2-6, carbon atoms or a pharmacologically acceptable salt thereof, and hydroxycitric acid or pantothenic acid or derivative thereof as active ingredients, and a pharmacologically acceptable excipient.
The composition of anyone of the preceding claims, wherein the weight ratio between hydroxycitric acid or derivative thereof and L-carnitine, alkanoyl L-carnitine or pharmacologically acceptable salt thereof is from 1:1 to 1:100, and wherein the weight ratio between pantothenic acid or derivative thereof and L-carnitine, alkanoyl L-carnitine or pharmacologically acceptable salt thereof is from 10:1 to 1:100.
The composition of anyone of the preceding claims which further comprises vitamins, mineral salts, antioxidants and vegetal fibers.
The composition of anyone of the preceding claims in a solid, semisolid, liquid, semiliquid, powder, granular or liposomic form, as tablets, capsules, granulates, powders and vials suitable for oral, parenteral, rectal or topic administration.
Co-ordinated use of L-carnitine or alkanoyl L-carnitine wherein the alkanoyl group has 2-8, preferably 2-6, carbon atoms, or pharmacologically acceptable salt thereof, and hydroxycitric acid or pantothenic acid or derivative thereof for treating cardiovascular, thromboembolic, atherosclerotic, hyperlipidaemic disorders and obesity, and for controlling and decreasing the appetite.
Dependencies are inferred from the claim text.