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US 2001/0011077 A1Published application
Secreted cysteine rich protein-6 (SCRP-6); polynucleotides and processes for producing polypeptides
OwnerEarl Francis Albone, Kristine Kay Kiklyinventors
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Abstract
The scrp-6 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing scrp-6 polypeptides and polynucleotides in therapy, and diagnostic assays for such.
Claims14
An isolated polypeptide selected from the group consisting of:
- (i) an isolated polypeptide comprising an amino acid sequence selected from the group having at least:
- (a) 70% identity;
- (b) 80% identity;
- (c) 90% identity;
- or
- (d) 95% identity
- to the amino acid sequence of SEQ ID NO:2 over the entire length of SEQ ID NO:2;
- (ii) an isolated polypeptide comprising the amino acid sequence of SEQ ID NO:2 or
- (iii) an isolated polypeptide which is the amino acid sequence of SEQ ID NO:2.
6 more elements
An isolated polynucleotide selected from the group consisting of:
- (i) an isolated polynucleotide comprising a nucleotide sequence encoding a polypeptide that has at least
- (a) 70% identity;
- (b) 80% identity;
- (c) 90% identity;
- or
- (d) 95% identity;
- to the amino acid sequence of SEQ ID NO:2, over the entire length of SEQ ID NO:2;
- (ii) an isolated polynucleotide comprising a nucleotide sequence that has at least:
- (a) 70% identity;
- (b) 80% identity;
- (c) 90% identity;
- or
- (d) 95% identity;
- over its entire length to a nucleotide sequence encoding the polypeptide of SEQ ID NO:2;
- (iii) an isolated polynucleotide comprising a nucleotide sequence which has at least:
- (a) 70% identity;
- (b) 80% identity;
- (c) 90% identity;
- or
- (d) 95% identity;
- to that of SEQ ID NO:1 over the entire length of SEQ ID NO:1;
- (iv) an isolated polynucleotide comprising a nucleotide sequence encoding the polypeptide of SEQ ID NO:2;
- (v) an isolated polynucleotide which is the polynucleotide of SEQ ID NO:1;
- or
- (vi) an isolated polynucleotide obtainable by screening an appropriate library under stringent hybridisation conditions with a labelled probe having the sequence of SEQ ID NO:1 or a fragment thereof;
- or a nucleotide sequence complementary to said isolated polynucleotide.
23 more elements
An agonist or an antagonist of the polypeptide of claim I.
An isolated polynucleotide selected form the group consisting of
- (a) an isolated polynucleotide comprising a nucleotide sequence which has at least 70%, 80%, 90%, 95%, 97% identity to SEQ ID NO:3 over the entire length of SEQ ID NO:3;
- (b) an isolated polynucleotide comprising the polynucleotide of SEQ ID NO:3;
- (c) the polynucleotide of SEQ ID NO:3;
- or
- (d) an isolated polynucleotide comprising a nucleotide sequence encoding a polypeptide which has at least 70%, 80%, 90%, 95%, 97-99% identity to the amino acid sequence of SEQ ID NO:4, over the entire length of SEQ ID NO:4.
2 more elements
A polypeptide selected from the group consisting of
- (a) a polypeptide which comprises an amino acid sequence which has at least 70%, 80%, 90%, 95%, 97-99% identity to that of SEQ ID NO:4 over the entire length of SEQ ID NO:4;
- (b) a polypeptide which has an amino acid sequence which is at least 70%, 80%, 90%, 95%, 97-99% identity to the amino acid sequence of SEQ ID NO:4 over the entire length of SEQ ID NO:4;
- (c) a polypeptide which comprises the amino acid of SEQ ID NO:4;
- (d) a polypeptide which is the polypeptide of SEQ ID NO:4;
- (e) a polypeptide which is encoded by a polynucleotide comprising the sequence contained in SEQ ID NO:3.
2 more elements
Dependencies are inferred from the claim text.