# US 12,766,121 B2 · Method for treating and/or preventing epilepsy and reducing side effect of anti-epileptic drug by using cynarin

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- Number: US 12,766,121 B2
- Document ID: US12766121B2
- Status: Granted
- Kind: B2
- Application number: 18/658,061
- Filed: 2024-05-08
- Published: 2025-10-02
- Granted: 2026-10-20
- Earliest claimed: 2024-04-01
- Assignees: Fu Jen Catholic University
- Applicants: Fu Jen Catholic University
- Inventors: Su-Jane Wang; Chi-Feng Hung; Wun-Jing Pan
- Web page: https://patentgrep.com/patent/US12766121B2

## CPC

- A61K 31/216: of acids having aromatic rings, e.g. benactizyne, clofibrate
- A61P 25/08: Antiepileptics; Anticonvulsants
- A61K 31/55: having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The present disclosure provides a method for treating and/or preventing epilepsy and reducing side effects of the anti-epileptic drug by using Cynarin. The Cynarin of the present disclosure achieves the effect of treating and/or preventing epilepsy and reducing side effects of the anti-epileptic drug through various efficacy experiments.

## Claims

### Claim 1

A method for treating and/or preventing epilepsy, comprising administering to a subject in need thereof a pharmaceutical composition comprising an effective amount of cynarin (CYN).

### Claim 2 (depends on 1)

The method according to claim 1, wherein the CYN prolongs the duration of epileptic seizure.

### Claim 3 (depends on 1)

The method according to claim 1, wherein the CYN reduces the severity of epileptic seizure.

### Claim 4 (depends on 1)

The method according to claim 1, wherein the CYN reduces the number of loss of nerve cells.

### Claim 5 (depends on 1)

The method according to claim 1, wherein the effective amount of CYN is 5-100 mg/kg.

### Claim 6 (depends on 1)

The method according to claim 1, wherein the pharmaceutical composition is in a dosage form for oral administration.

### Claim 7 (depends on 1)

The method according to claim 1, wherein the pharmaceutical composition is in a dosage form for parenteral administration.

### Claim 8

A method for reducing side effects of an anti-epileptic drug, comprising administering to a subject in need thereof a pharmaceutical composition comprising an effective amount of cynarin (CYN).

### Claim 9 (depends on 8)

The method according to claim 8, wherein the anti-epileptic drug is carbamazepine (CBZ).

### Claim 10 (depends on 8)

The method according to claim 8, wherein the effective amount of CYN is 5-25 mg/kg.

### Claim 11 (depends on 8)

The method according to claim 8, wherein the pharmaceutical composition is in a dosage form for oral administration.

### Claim 12 (depends on 8)

The method according to claim 8, wherein the pharmaceutical composition is in a dosage form for parenteral administration.