Copper-64 compositions and formulations
AssigneeCurium US LLC
InventorsDavid Pipes, William Uhland, Brian Regna, Craig Brunkhorst
Life of this patent
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Abstract
The present disclosure is directed compositions and formulations comprising high levels of high specific activity copper-64, and process for preparing said compositions. The compositions comprise from about 2 Ci or greater of copper-64 and have specific activities up to about 3850 mCi copper-64 per microgram of copper. The processes for preparing said compositions comprise bombarding a nickel-64 target with a low energy, high current proton beam, and purifying the copper-64 from other metals by a process comprising ion exchange chromatography or a process comprising a combination of extraction chromatography and ion exchange chromatography.
Claims17
A composition comprising 2 Ci of copper-64 (64Cu) or greater, wherein the composition has a specific activity from about 5 mCi 64Cu/μg Cu to about 3850 mCi 64Cu/μg Cu and wherein the composition comprises chemical and radionuclidic purities suitable for positron emission tomography (PET).
A composition comprising 2 Ci of copper-64 (64Cu) or greater, wherein the composition comprises chemical and radionuclidic purities suitable for positron emission tomography (PET), and wherein the composition has a total content of trace metals of less than about 5 parts per million (ppm), the trace metals being cobalt, copper, gold, iron, lead, mercury, nickel, and zinc.
A composition comprising 2 Ci of copper-64 (64Cu) or greater, wherein the composition has a specific activity from about 25 mCi 64Cu/μg Cu to about 3850 mCi 64Cu/μg Cu, and wherein the composition comprises chemical and radionuclidic purities suitable for positron emission tomography (PET).
Dependencies are inferred from the claim text.