Adapting array layouts to account for tumor progression

An apparatus for selecting at least one transducer layout for delivering tumor treating fields to a subject, the apparatus comprising:

• one or more processors;
• and memory accessible by the one or more processors, the memory storing instructions that when executed by the one or more processors, cause the apparatus to:
• obtain a three-dimensional model of the subject, the model comprising voxels;
• identify a gross tumor volume for the three-dimensional model, the gross tumor volume representing a current location of a tumor in the subject;
• identify a primary clinical target volume for the three-dimensional model, the primary clinical target volume having a larger volume than the gross tumor volume, the primary clinical target volume representing an approximation of the current location of the tumor in the subject;
• identify a predictive clinical target volume for the three-dimensional model, the predictive clinical target volume having a larger volume than the primary clinical target volume, the predictive clinical target volume is based on a progression of the tumor in the subject over a period of time;
• determine a plurality of transducer layouts for delivering tumor treating fields to the subject;
• calculate tumor treating fields dosages for the plurality of transducer layouts based on the three-dimensional model of the subject and the predictive clinical target volume, wherein calculating the tumor treating fields dosages for the plurality of transducer layouts comprises simulating applying alternating electric fields to the three-dimensional model of the subject for each of the plurality of transducer layouts, wherein simulating applying the alternating electric fields comprises computing, for individual voxels of the three-dimensional model, electric field distributions based on electrical properties assigned to each voxel;
• and
• select at least one transducer layout from the plurality of transducer layouts for delivering tumor treating fields to the subject based on the primary clinical target volume, the predictive clinical target volume, and the tumor treating fields dosages for the plurality of transducer layouts.

A non-transitory processor readable medium for selecting at least one transducer layout for delivering tumor treating fields to a subject and containing a set of instructions thereon that when executed by a processor cause the processor to:

• obtain a three-dimensional model of the subject, the model comprising voxels;
• identify a gross tumor volume for the three-dimensional model, the gross tumor volume representing a current location of a tumor in the subject;
• identify a primary clinical target volume for the three-dimensional model, the primary clinical target volume having a larger volume than the gross tumor volume, the primary clinical target volume representing an approximation of the current location of the tumor in the subject;
• identify a predictive clinical target volume for the three-dimensional model, the predictive clinical target volume having a larger volume than the primary clinical target volume, the predictive clinical target volume representing a predicted future location of the tumor in the subject;
• determine a plurality of transducer layouts for delivering tumor treating fields to the subject;
• calculate tumor treating fields dosages for the plurality of transducer layouts based on the three-dimensional model of the subject and the predictive clinical target volume, wherein calculating the tumor treating fields dosages for the plurality of transducer layouts comprises simulating applying alternating electric fields to the three-dimensional model of the subject for each of the plurality of transducer layouts, wherein simulating applying the alternating electric fields comprises computing, for individual voxels of the three-dimensional model, electric field distributions based on electrical properties assigned to each voxel;
• and
• select at least one transducer layout from the plurality of transducer layouts for delivering tumor treating fields to the subject based on tumor treating fields dosages for the primary clinical target volume, the predictive clinical target volume, and the tumor treating fields dosages for the plurality of transducer layouts.