Determining patient state and next-best actions with therapeutic interventions

A computer system for improving a medical diagnosis when determining a state of a patient across heterogeneous medical ontologies, said computer system comprising:

• one or more processors;
• and
• memory storing computer code that, when executed by said one or more processors, causes said computer system to perform operations comprising:
• receiving a plurality of diagnostic factors known to be present or absent in a patient and a plurality of therapies known to be used or not used by said patient;
• matching said diagnostic factors to factor nodes in a knowledge graph and matching said therapies to therapeutic intervention nodes in said knowledge graph, said knowledge graph including a plurality of medical condition nodes linked to said factor nodes and to said therapeutic intervention nodes, wherein at least one of said factor nodes stores an ontology link to an entry in a diagnostic medical ontology that defines a diagnostic factor, wherein at least one of said therapeutic intervention nodes stores an ontology link to an entry in an intervention medical ontology that defines a therapy, and wherein said diagnostic and intervention medical ontologies are different from one another and are traversable from said knowledge graph;
• collecting a diagnostic ranking value from along a path from said each matched diagnostic factor node to its linked medical condition node, said each diagnostic ranking value being indicative of the likelihood of a medical condition represented by said each medical condition node, and collecting a therapeutic ranking value from along a path from said each matched therapeutic intervention node to its linked medical condition node, said each therapeutic ranking value being indicative of the likelihood of a therapy of said each matched therapeutic intervention node being used to treat a medical condition represented by said each medical condition node;
• combining all collected rank values for each linked medical condition node to produce a final ranking value for said each linked medical condition node;
• and
• outputting said medical condition representing said each medical condition node based upon said final ranking value of said each medical condition node.