# US 12,763,203 B2 · Systems and methods for optimizing medical care through data monitoring and feedback treatment > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 12,763,203 B2 - Document ID: US12763203B2 - Status: Granted - Kind: B2 - Application number: 19/296,080 - Filed: 2025-08-11 - Published: 2026-02-05 - Granted: 2026-10-13 - Earliest claimed: 2011-03-04 - Assignees: Etiometry Inc. - Applicants: Etiometry Inc. - Inventors: Dimitar V. Baronov; Evan J. Butler; Jesse M. Lock - Web page: https://patentgrep.com/patent/US12763203B2 ## CPC - G16H 40/63: for local operation - A61B 5/0205: Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition - A61M 5/1723: {using feedback of body parameters, e.g. blood sugar or pressure} - A61M 16/0003: {Accessories therefor, e.g. sensors, vibrators, negative pressure} - A61M 27/002: {Implant devices for drainage of body fluids from one part of the body to another (intraocular A61F9/00781; middle ear A61F11/202)} - G16H 20/10: relating to drugs or medications, e.g. for ensuring correct administration to patients - G16H 50/20: for computer-aided diagnosis, e.g. based on medical expert systems - G16H 50/50: for simulation or modelling of medical disorders - A61B 5/02: Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow - A61B 5/14532: {for measuring glucose, e.g. by tissue impedance measurement} - A61B 5/14542: {for measuring blood gases (A61B5/14551 takes precedence)} - A61B 5/14546: {for measuring analytes not otherwise provided for, e.g. ions, cytochromes} - A61B 5/1455: using optical sensors, e.g. spectral photometrical oximeters - G16H: HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) - A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)} ## Abstract Systems, methods, and computer-readable media for providing a decision support solution to medical professionals to optimize medical care through data monitoring and feedback treatment are provided herein. In another embodiment, a computer-implemented method for modeling patient outcomes resulting from treatment in a specific medical area includes receiving patient-specific data associated with a patient, determining a plurality of possible patient states under which the patient can be categorized, a current patient state under which the patient can be categorized and determining probabilities of the patient transitioning from any of the possible patient states to every other possible patient state. ## Claims ### Claim 1 A system for event-driven patient monitoring and treatment of a patient comprising: a computer processor; a memory coupled to the processor, the memory having computer-executable instructions stored thereon, which when executed by the processor, cause the processor to: receive patient-specific data associated with the patient, the patient-specific data comprising at least data from a blood oximeter coupled with the patient; determine a plurality of physiological variables based on the received patient-specific data, the plurality of physiological variables including at least oxygen saturation; define a state space partitioned into a plurality of possible clinical patient states defined by a plurality of boundaries, the plurality of possible patient states comprising: (i) inadequate DO2 along with normal Qp/Qs; (ii) adequate DO2 along with high Qp/Qs; and (iii) inadequate DO2 along with high Qp/Qs; wherein a boundary between adequate DO2 and inadequate DO2 is 25 ml O2/min/kg; determine from the patient-specific data, a current clinical patient state of the patient within the state space, the current clinical patient state being one of: (a) inadequate DO2 along with normal Qp/Qs; (b) adequate DO2 along with high Qp/Qs; and (c) inadequate DO2 along with high Qp/Qs; and send a signal to a treatment device coupled to the patient so that the signal causes the treatment device to administer a treatment to the patient, the treatment known to address the current clinical patient state. ### Claim 2 (depends on 1) The system of claim 1: wherein a boundary between normal Qp/Qs and high Qp/Q is a ratio of 1.5, such that the patient state of adequate DO2 along with high Qp/Qs is defined by DO2 greater than 25 ml O2/min/kg along with Qp/Qs greater than a ratio of 1.5, and such that the patient state of inadequate DO2 along with high Qp/Qs is defined by DO2 less than 25 ml O2/min/kg along with Qp/Qs greater than a ratio of 1.5, and such that the patient state of inadequate DO2 along with normal Qp/Qs is defined by DO2 less than 25 ml O2/min/kg along with Qp/Qs less than a ratio of 1.5. ### Claim 3 (depends on 1) The system of claim 1, wherein (x) the treatment for inadequate DO2 along with normal Qp/Qs, and the treatment for inadequate DO2 along with high Qp/Qs, is administration of chronotropic medication; and (y) the treatment for adequate DO2 along with high Qp/Qs is administration of vasodilation medication. ### Claim 4 A method for event driven patient monitoring and treatment of a patient comprising: receiving, at a computer, patient-specific data associated with the patient, the patient-specific data comprising at least data from a blood oximeter coupled with the patient; determining, by the computer, a plurality of physiological variables based on the received patient-specific data; defining, by the computer, a state space partitioned into the plurality of possible clinical patient states defined by a plurality of boundaries, including a boundary between adequate DO2 and inadequate DO2, and a boundary between normal Qp/Qs and high Qp/Q, the plurality of possible patient states comprising: (i) inadequate DO2 along with normal Qp/Qs; (ii) adequate DO2 along with high Qp/Qs; and (iii) inadequate DO2 along with high Qp/Qs; wherein a boundary between adequate DO2 and inadequate DO2 is 25 ml O2/min/kg; determining, by the computer, from the physiological variables, a current clinical patient state within the state space, the current clinical patient state being one of: inadequate DO2 along with normal Qp/Qs; adequate DO2 along with high Qp/Qs; and inadequate DO2 along with high Qp/Qs; and sending a signal from the computer to a treatment device coupled to the patient so that the signal causes the treatment device to administer a treatment to the patient, the treatment known to address the current clinical patient state. ### Claim 5 (depends on 4) The method of claim 4: wherein a boundary between normal Qp/Qs and high Qp/Q is a ratio of 1.5, such that the patient state of adequate DO2 along with high Qp/Qs is defined by DO2 greater than 25 ml O2/min/kg along with Qp/Qs greater than a ratio of 1.5, and such that the patient state of inadequate DO2 along with high Qp/Qs is defined by DO2 less than 25 ml O2/min/kg along with Qp/Qs greater than a ratio of 1.5, and such that the patient state of inadequate DO2 along with normal Qp/Qs is defined by DO2 less than 25 ml O2/min/kg along with Qp/Qs less than a ratio of 1.5. ### Claim 6 (depends on 4) The method of claim 4, wherein (x) the treatment for inadequate DO2 along with normal Qp/Qs, and the treatment for inadequate DO2 along with high Qp/Qs, is administration of chronotropic medication; and (y) the treatment for adequate DO2 along with high Qp/Qs is administration of vasodilation medication. ### Claim 7 A non-transitory computer-readable medium having computer-executable instructions stored thereon, the instructions executable by a computer, the instructions comprising: instructions to cause the computer to receive patient-specific data associated with the patient, the patient-specific data comprising at least data from one of a plurality of sensors coupled with the patient, the plurality of sensors including at least a blood oximeter; instructions to cause the computer to determine a plurality of physiological variables based on the received patient-specific data, the plurality of physiological variables including at least oxygen saturation; instructions to cause the computer to define a state space partitioned into a plurality of possible clinical patient states defined by a plurality of boundaries, the plurality of possible patient states comprising: (i) inadequate DO2 along with normal Qp/Qs; (ii) adequate DO2 along with high Qp/Qs; and (iii) inadequate DO2 along with high Qp/Qs; wherein a boundary between adequate DO2 and inadequate DO2 is 25 ml O2/min/kg; instructions to cause the computer to determine from the physiological variables, a current clinical patient state of the patient within the state space, the current clinical patient state being one of: (a) inadequate DO2 along with normal Qp/Qs; (b) adequate DO2 along with high Qp/Qs; and (c) inadequate DO2 along with high Qp/Qs; and instructions to cause the computer to control a treatment device by sending a signal to the treatment device coupled to the patient so that the signal causes the treatment device to administer a treatment to the patient, the treatment known to address the current clinical patient state. ### Claim 8 (depends on 7) The non-transitory computer-readable medium of claim 7: wherein a boundary between normal Qp/Qs and high Qp/Q is a ratio of 1.5, such that the patient state of adequate DO2 along with high Qp/Qs is defined by DO2 greater than 25 ml O2/min/kg along with Qp/Qs greater than a ratio of 1.5, and such that the patient state of inadequate DO2 along with high Qp/Qs is defined by DO2 less than 25 ml O2/min/kg along with Qp/Qs greater than a ratio of 1.5, and such that the patient state of inadequate DO2 along with normal Qp/Qs is defined by DO2 less than 25 ml O2/min/kg along with Qp/Qs less than a ratio of 1.5. ### Claim 9 (depends on 7) The non-transitory computer-readable medium of claim 7, wherein (x) the treatment for inadequate DO2 along with normal Qp/Qs, and the treatment for inadequate DO2 along with high Qp/Qs is administration of chronotropic medication; and (y) the treatment for adequate DO2 along with high Qp/Qs is administration of vasodilation medication.