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AssigneeThe United States of America, as represented by the Secretary, Department of Health and Human Services
InventorsFrank J. Lowery, III, Sri Krishna, Paul F. Robbins, Steven A. Rosenberg, Gregoire Y. Altan-Bonnet
Estimating the term…
Disclosed are methods of obtaining a cell population enriched for T cells with a phenotype, the method comprising: (a) obtaining a bulk population of T cells from a tumor sample of a patient; (b) specifically selecting T cells with a phenotype comprising markers CD3+, CD39−, and CD69− from the bulk population; and (c) separating the cells selected in (b) from cells which lack the phenotype to obtain a cell population enriched for T cells with the phenotype. Related methods of treating or preventing cancer, methods of selecting a therapy for a cancer patient, and methods for predicting the clinical response to immunotherapy in a cancer patient are also disclosed. Isolated or purified cell population obtained according to the methods and related pharmaceutical compositions are also disclosed.
A method of obtaining a cell population enriched for T cells with a phenotype, the method comprising:
A method of obtaining a cell population enriched for T cells with a phenotype, the method comprising:
A method of obtaining a cell population enriched for T cells with a phenotype, the method comprising:
A method of preparing a population of cells enriched for T cells with a CD3+CD39−CD69− phenotype, the method comprising:
Dependencies are inferred from the claim text.