Substance detection device
AssigneeRiken
InventorTakuo Tanaka
Life of this patent
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Abstract
Provided is an easy to determine immunochromatography detection device that detects a target substance that may be contained in a sample fluid. The detection device includes a flow path for the sample fluid and detection parts 1 to which capture selected substances. In one embodiment, an Metal-Insulator-Metal (MIM) structure is formed when the target substance is included in the sample fluid at the detection parts, and a color is produced at the detection parts by resonance absorption. The MIM structure comprises a metal thin film (M layer) that is formed on a support that acts as either a capture substance/target substance/reference substance composite layer or a capture substance/reference substance composite layer (I layer), and metal fine particles (M layer) with which a reference substance is labeled.
Claims14
A detection device for detecting a target substance that may be contained in a sample fluid, comprising:
- a flow path for the sample fluid to which a reference substance is dispersed, the reference substance being capable of physicochemically binding to the target substance;
- and
- at least one detection part disposed in the flow path, the detection part being visible and having a capture substance fixed to at least part of a contact surface thereof,
- wherein the reference substance is labeled by fine particles,
- wherein the capture substance can bind physicochemically to at least one of the target substance that is bound to the reference substance, or to the reference substance,
- wherein the fine particles form an assembly along the contact surface and produce a color, the assembly being formed by the physicochemical binding of the target substance, which binds to at least one of the reference substance and the capture substance, or the physicochemical binding of the reference substance to the capture substance,
- wherein the fine particles are metal fine particles,
- wherein the at least one detection part has a metal thin film formed on a support member,
- wherein the at least one detection part is configured to form a metal-insulator-metal (MIM) structure when the target substance is contained in the sample fluid, the MIM structure including:
- the metal thin film;
- at least one of a composite layer of the capture substance, the target substance, and the reference substance, or a composite layer of the capture substance and the reference substance;
- and
- an assembly of the metal fine particles,
- wherein the at least one detection part includes a test part provided in an upstream side of the flow path and a control part provided in a downstream side of the flow path,
- wherein the test part has a first capture substance for the capture substance of the test part, the first capture substance fixed to a surface contacting the sample fluid,
- wherein the control part has a second capture substance for the capture substance of the control part, the second capture substance fixed to a surface contacting the sample fluid,
- wherein the MIM structure in the test part includes the metal thin film, a composite layer of the first capture substance, the target substance, and the reference substance, and an assembly of the metal fine particles, and
- wherein the MIM structure in the control part consists of the metal thin film, a composite layer of the second capture substance and the reference substance, and an assembly of the metal fine particles.
A detection device for detecting a target substance that may be contained in a sample fluid, comprising:
- a flow path for the sample fluid to which a reference substance is dispersed, the reference substance being capable of physicochemically binding to the target substance;
- and
- at least one detection part disposed in the flow path, the detection part being visible and having a capture substance fixed to at least part of a contact surface thereof,
- wherein the reference substance is labeled by fine particles,
- wherein the capture substance can bind physicochemically to at least one of the target substance that is bound to the reference substance, or to the reference substance,
- wherein the fine particles form an assembly along the contact surface and produce a color, the assembly being formed by the physicochemical binding of the target substance, which binds to at least one of the reference substance and the capture substance, or the physicochemical binding of the reference substance to the capture substance,
- wherein the fine particles are metal fine particles,
- wherein the at least one detection part has a metal thin film formed on a support member,
- wherein the at least one detection part is configured to form a metal-insulator-metal (MIM) structure when the target substance is contained in the sample fluid, the MIM structure including:
- the metal thin film;
- at least one of a composite layer of the capture substance, the target substance, and the reference substance, or a composite layer of the capture substance and the reference substance;
- and
- an assembly of the metal fine particles, and
- wherein the at least one detection part further comprises:
- a transparent dielectric thin film disposed on the metal thin film;
- and
- an additional metal thin film layer that is patterned and disposed on the transparent dielectric thin film,
- wherein the capture substance is disposed in a location where the additional metal thin film layer is not disposed.
Dependencies are inferred from the claim text.