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US 12,761,216 B2Granted
System and sensor array
AssigneeThe Brigham and Women's Hospital, Inc.
InventorsOmid Farokhzad, Morteza Mahmoudi, Claudia Corbo
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Abstract
The present disclosure provides a system comprising a communication interface and computer for assigning a label to the biomolecule fingerprint, wherein the label corresponds to a biological state. The present disclosure also provides a sensor arrays for detecting biomolecules and methods of use. In some embodiments, the sensor arrays are capable of determining a disease state in a subject.
Claims23
A method for determining a biological state in a mammalian subject by assaying a biological sample obtained from the mammalian subject, comprising:
- (a) incubating a plurality of sensor elements in a sample volume of the biological sample, wherein the plurality of sensor elements comprises different physicochemical properties to adsorb a plurality of biomolecules on respective surfaces of the plurality of sensor elements, wherein at least a first subset of the plurality of sensor elements differs from at least a second subset of the plurality of sensor elements based on a physicochemical property;
- (b) separating at least a portion of the plurality of biomolecules from the plurality of sensor elements to provide a plurality of separated biomolecules;
- (c) performing mass spectrometry on the plurality of separated biomolecules to detect a plurality of detected biomolecules, wherein the plurality of detected biomolecules include detected proteins present in the biological sample at concentrations across a dynamic range exceeding six orders of magnitude;
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- (d) determining the biological state in the mammalian subject based on the plurality of detected biomolecules.
2 more elements
Dependencies are inferred from the claim text.