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US 12,761,211 B2Granted
Compositions and methods for making and using three-dimensional tissue systems
AssigneeMilica Radisic
InventorsBoyang Zhang, Yimu Zhao, Milica Radisic
Life of this patent
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Abstract
The present disclosure provides methods, compositions, and devices for making and using three-dimensional biological tissues that accurately mimic native physiology, architecture, and other properties of native tissues for use in, among other applications, drug testing, tissue repair and/or treatment, and regenerative medicine.
Claims20
A device comprising:
- a longitudinal channel for tissue cultivation;
- and
- a perfusable tube scaffold suspended longitudinally in the channel for cultivating a tissue structure, wherein the perfusable tube scaffold has a lumen configured to perfuse the tissue structure, the lumen having a diameter in a range of 2.0-200 microns;
- and wherein the perfusable tube scaffold comprises nano-pores and micro-holes.
1 more element
A method for cultivating tissues, comprising:
- providing a device including:
- a longitudinal channel for tissue cultivation;
- and
- a perfusable tube scaffold suspended longitudinally in the channel for cultivating a tissue structure, wherein the perfusable tube scaffold has a lumen configured to perfuse the tissue structure, the lumen having a diameter in a range of 2.0-200 microns, and wherein the perfusable tube scaffold comprises nano-pores and micro-holes;
- introducing seed cells into the channel of the device;
- and
- culturing the seed cells in the channel.
4 more elements
A device comprising:
- a chamber for tissue cultivation and a scaffold having a branching channel network for cultivating a tissue structure;
- wherein the scaffold is a perfusable tube scaffold having a lumen configured to perfuse the tissue structure, the lumen having a diameter in a range of 2.0-200 microns, and wherein the perfusable tube scaffold comprises nano-pores and micro-holes.
Dependencies are inferred from the claim text.