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US 12,761,149 B2Granted
Devices, systems, and methods for chiral sensing
AssigneeBoard of Regents, The University of Texas System
InventorsYuebing Zheng, Kumar Sharma, Yaoran Liu, Zilong Wu
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Abstract
Disclosed herein is a device for chiral sensing comprising a chiral plasmonic substrate, wherein when the device is assembled together with a first light source, a liquid sample comprising a plurality of chiral analytes, a second light source, and an instrument, the first light source is configured to illuminate the chiral plasmonic substrate with electromagnetic radiation; and the second light source is configured to illuminate the chiral plasmonic substrate with circularly polarized electromagnetic radiation. The instrument is configured to process electromagnetic signal from the first light source and the second light source to determine a property of the liquid sample.
Claims21
A method comprising:
- illuminating a first location of a chiral plasmonic substrate with electromagnetic radiation;
- wherein the electromagnetic radiation comprises a wavelength that overlaps with at least a portion of the plasmon resonance energy of the chiral plasmonic substrate such that the chiral plasmonic substrate converts at least a portion of the electromagnetic radiation into thermal energy;
- and
- wherein the chiral plasmonic substrate is in thermal contact with a liquid sample comprising a plurality of chiral analytes;
- thereby:
- generating a bubble at a location in the liquid sample proximate to the first location of the chiral plasmonic substrate via plasmon-enhanced photothermal effects, the bubble having a gas-liquid interface with the liquid sample and a gas-solid interface with the chiral plasmonic substrate;
- trapping at least a portion of the plurality of chiral analytes at the gas-liquid interface of the bubble and the liquid sample, said portion of the plurality of chiral analytes trapped at the gas-liquid interface being a trapped portion of the plurality of chiral analytes;
- and
- depositing at least a portion of the trapped portion of the plurality of chiral analytes on the chiral plasmonic substrate proximate to the gas-solid interface of the bubble and the chiral plasmonic substrate, said portion of the trapped portion of the plurality of chiral analytes deposited on the chiral plasmonic substrate being a deposited portion of the plurality of chiral analytes;
- and
- illuminating at least a portion of the deposited portion of the plurality of chiral analytes and at least the portion of the chiral plasmonic substrate at which the deposited portion of the plurality of chiral analytes is located with circularly polarized electromagnetic radiation, said portion of the deposited portion of the plurality of chiral analytes illuminated with the circularly polarized electromagnetic radiation being an illuminated portion of the deposited portion of the plurality of chiral analytes and said portion of the chiral plasmonic substrate at which the deposited portion of the plurality of chiral analytes is located illuminated with the circularly polarized electromagnetic radiation being an illuminated portion of the chiral plasmonic substrate;
- capturing an electromagnetic signal from:
- the illuminated portion of the deposited portion of the plurality of chiral analytes, the illuminated portion of the chiral plasmonic substrate, or a combination thereof, wherein the circularly polarized electromagnetic radiation passes through both the illuminated portion of the deposited portion of the plurality of chiral analytes and the illuminated portion of the chiral plasmonic substrate before being captured;
- and
- processing the electromagnetic signal to determine a property of the liquid sample.
12 more elements
A system comprising:
- a chiral plasmonic substrate;
- a liquid sample comprising a plurality of chiral analytes, the liquid sample being in thermal contact with the chiral plasmonic substrate;
- a first light source configured to illuminate a first location of the chiral plasmonic substrate with electromagnetic radiation;
- wherein electromagnetic radiation comprises a wavelength that overlaps with at least a portion of the plasmon resonance energy of the chiral plasmonic substrate such that the chiral plasmonic substrate converts at least a portion of the electromagnetic radiation into thermal energy;
- thereby:
- generating a bubble at a location in the liquid sample proximate to the first location of the chiral plasmonic substrate via plasmon-enhanced photothermal effects, the bubble having a gas-liquid interface with the liquid sample and a gas-solid interface with the chiral plasmonic substrate;
- trapping at least a portion of the plurality of chiral analytes at the gas-liquid interface of the bubble and the liquid sample, said portion of the plurality of chiral analytes trapped at the gas-liquid interface being a trapped portion of the plurality of chiral analytes;
- and
- depositing at least a portion of the trapped portion of the plurality of chiral analytes on the chiral plasmonic substrate proximate to the gas-solid interface of the bubble and the chiral plasmonic substrate, said portion of the trapped portion of the plurality of chiral analytes deposited on the chiral plasmonic substrate being a deposited portion of the plurality of chiral analytes;
- and
- a second light source configured to illuminate at least a portion of the deposited portion of the plurality of chiral analytes and at least the portion of the chiral plasmonic substrate at which the deposited portion of the plurality of chiral analytes is located with circularly polarized electromagnetic radiation, said portion of the deposited portion of the plurality of chiral analytes illuminated with the circularly polarized electromagnetic radiation being an illuminated portion of the deposited portion of the plurality of chiral analytes and said portion of the chiral plasmonic substrate at which the deposited portion of the plurality of chiral analytes is located illuminated with the circularly polarized electromagnetic radiation being an illuminated portion of the chiral plasmonic substrate;
- an instrument configured to capture an electromagnetic signal from:
- the illuminated portion of the deposited portion of the plurality of chiral analytes, the illuminated portion of the chiral plasmonic substrate, or a combination thereof, wherein the circularly polarized electromagnetic radiation passes through both the illuminated portion of the deposited portion of the plurality of chiral analytes and the illuminated portion of the chiral plasmonic substrate before being captured;
- and
- the instrument being further configured to process the electromagnetic signal to determine a property of the liquid sample.
12 more elements
Dependencies are inferred from the claim text.