Isolation device and isolation method
AssigneeShenzhen Huixin Life Technologies Co., Ltd
InventorsYijie Yang, Yuchao Chen
Life of this patent
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Abstract
An isolation device includes an isolation chip, a pressing assembly, two ultrasonic generators, a differential pressure driving system, a frequency conversion module, and a controller. The isolation chip includes a sample reservoir, a first chamber, and a second chamber. The pressing assembly drives the two ultrasonic generators to move towards the isolation chip to make in contact with the first and second chambers. The frequency conversion module controls the differential pressure driving system to generate a negative pressure in the first and second chambers alternately. The controller controls the two ultrasonic generators to generate two ultrasonic waves when negative pressures are cancelled in the first and second chambers. An isolation method is also disclosed.
Claims9
An isolation device for isolation of target particles from a liquid sample, comprising:
- an isolation chip comprising:
- a sample reservoir configured for receiving the liquid sample;
- at least one first chamber disposed on a side of the sample reservoir;
- and
- at least one second chamber disposed on another side of the sample reservoir away from the at least one first chamber, wherein one of the at least one first chamber closest to the sample reservoir is connected to the sample reservoir through first filtration membrane, one of the at least one second chamber closest to the sample reservoir is connected to the sample reservoir through second filtration membrane, each of an average pore size of the first filtration membrane and an average pore size of the second filtration membrane is smaller than a size of the target particles;
- an oscillation system comprising:
- a pressing assembly;
- and
- two ultrasonic generators disposed on the pressing assembly, wherein the pressing assembly is configured to drive the two ultrasonic generators to move towards the isolation chip to make in contact with an outer surface of an outermost one of the at least one first chamber and an outer surface of an outermost one of the at least one second chamber;
- a differential pressure driving system;
- a frequency conversion module connected to the outermost one of the at least one first chamber and the outermost one of the at least one second chamber through the differential pressure driving system, the frequency conversion module configured to control the differential pressure driving system to generate a negative pressure in the at least one first chamber and the at least one second chamber alternately;
- and
- a controller configured to control the two ultrasonic generators to vibrate to generate two ultrasonic waves when the differential pressure driving system stops to generate the negative pressure in the at least one first chamber or the at least one second chamber, the controller further configured to power on and power off the two ultrasonic generators, within a period of the power on and the power off, a ratio of the power on is 10% to 100%.
Dependencies are inferred from the claim text.