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US 12,760,376 B2Granted
DNAzyme for Clostridium difficile detection
AssigneeMcMaster University
InventorsYingfu Li, Shuwen Qian, Dingran Chang, Jimmy Gu, Bruno Salena
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Abstract
This disclosure relates to catalytic nucleic acids, catalytic nucleic acid probes, biosensors, and kits for detecting the presence of Clostridium difficile. Also provided are methods for detecting the presence of Clostridium difficile in a test sample, using the catalytic nucleic acids, catalytic nucleic acid probes, biosensors, and kits.
Claims20
A catalytic nucleic acid for detecting Clostridium difficile comprising the sequence selected from the group consisting of SEQ ID NO:
- 11, 15-16, 19-21, 23, 29-32, 36-37, 39-44, and 47 or a functional fragment or variant thereof, wherein the functional fragment or variant comprises a first domain comprising nucleotides 21-41 of SEQ ID NO:
- 11 and a second domain comprising nucleotides 61-78 of SEQ ID NO:
- 11;
- or the catalytic nucleic acid comprises one of SEQ ID NO:
- 10, 12, 13, or 14.
2 more elements
Dependencies are inferred from the claim text.