US 12,760,302 B2 · Polynucleotide and pharmaceutical composition

Polynucleotide and pharmaceutical composition

AssigneesNational University Corporation Tokai National Higher Education and Research System, Kyowa Kirin Co., Ltd.

InventorsHiroshi Abe, Hiroto Iwai, Masakazu Homma, Kana Asano, Kenji Harada, Junichiro Yamamoto, Fumikazu Shinohara, Keiichi Motosawa, Yasuaki Kimura, Kosuke Nakamoto

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Abstract

An object of the present invention is to provide a polynucleotide having a modification site in a translated region with translation activity retained. The object can be achieved by a polynucleotide containing a translated region from a start codon to a stop codon, in which the translated region contains n codons, and the n is a positive integer of 2 or more, each of the n codons contains first, second and third nucleotides, and the first nucleotides in at least two codons of the n codons are sugar modified nucleotides.

Claims25

Dependent claims

A polynucleotide comprising a translated region from a start codon to a stop codon,

wherein the translated region contains n codons, and the n is a positive integer of 2 or more,
each of the n codons contains first, second and third nucleotides,
the first nucleotides in at least two codons of the n codons are sugar modified nucleotides, and
the first, second and third nucleotides in the stop codon are sugar modified nucleotides.

1 more element

Dependencies are inferred from the claim text.