Stabilized amorphous calcium carbonate as a supplement for cell culture media
AssigneeAmorphical Ltd.
InventorsYosef Ben, Yigal Dov Blum, Sara Neuman, Orit Ecker
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Abstract
Stabilized amorphous calcium carbonate (ACC) as a supplement of cell culture media and the cell culture medium supplements comprising stabilized ACC are provided. In particular the stabilized ACC is useful for enhancing the growth of cell and tissue cultures, gametes and embryos in vitro and particularly in microgravity.
Claims19
A method for (i) enhancing growth of a biological culture, (ii) supporting growth of a biological culture, or (iii) both (i) and (ii) in microgravity conditions, the method comprising:
- growing the biological culture in a cell culture medium comprising an amorphous calcium carbonate (ACC) stabilized by at least one stabilizer;
- wherein the growth of the biological culture is performed in microgravity conditions;
- and wherein the ACC maintains a greater proportion of viable cells in the biological culture in microgravity compared to an equimolar concentration of calcium chloride.
A method of preventing a loss in the mass of a musculoskeletal system in space microgravity, in a subject in need thereof, the method comprising:
- administering to said subject an amorphous calcium carbonate (ACC) stabilized by at least one stabilizing agent, wherein the ACC is administered in a dose that prevents bone or muscle mass loss more effectively than an equimolar dose of crystalline calcium carbonate.
A method of treating damages caused by exposure to microgravity conditions in a subject in need thereof, the method comprising:
- administering to said subject an amorphous calcium carbonate (ACC) stabilized by at least one stabilizing agent, wherein the ACC treats said damages to a greater extent than a equimolar dose of crystalline calcium carbonate.
Dependencies are inferred from the claim text.