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US 12,760,119 B2Granted
Heterodimeric antibodies that bind ENPP3 and CD3
AssigneeXencor, Inc.
InventorsRumana Rashid, Umesh S. Muchhal, Gregory Moore, Alex Nishtal, Seung Chu, Sung-Hyung Lee, Yoon Kyung Kim
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Abstract
The present invention is directed to antibodies, including novel antigen binding domains and heterodimeric antibodies, that bind Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 (ENPP3).
Claims10
A composition comprising an Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 (ENPP3) binding domain comprising:
- a) a variable heavy domain having the amino acid sequence of SEQ ID NO:218, and a variable light domain having the amino acid sequence of SEQ ID NO:222;
- b) a variable heavy domain having the amino acid sequence of SEQ ID NO:244, and a variable light domain having the amino acid sequence of SEQ ID NO:248;
- c) a variable heavy domain having the amino acid sequence of SEQ ID NO:252, and a variable light domain having the amino acid sequence of SEQ ID NO:256;
- and
- d) a variable heavy domain having the amino acid sequence of SEQ ID NO:260, and a variable light domain having the amino acid sequence of SEQ ID NO:264.
2 more elements
Dependencies are inferred from the claim text.