US 12,760,109 B2Granted

Anti BDCA-2 antibodies

AssigneeCentessa Pharmaceuticals (UK) Limited

InventorSteve Holmes

Life of this patent

Estimating the term…

Abstract

The present invention relates antigen binding molecules, particularly antibodies, fragments and variants thereof, that bind to BDCA-2 (CLEC4C), and the use of said antigen binding molecules in treating and/or preventing inflammatory disorders and immune disorders such as autoimmune diseases.

Claims25

Dependent claims

An anti-BDCA-2 (CLEC4C) antigen binding molecule comprising

(a)
a heavy chain variable region comprising a VHCDR1 comprising the amino acid sequence SYTMS (SEQ ID NO:
46), a VHCDR2 comprising the amino acid sequence YISSGGGQTYYPDSVKG (SEQ ID NO:
47), a VHCDR3 comprising the amino acid sequence HDYYEGGLYYAMDY (SEQ ID NO:
48);
and
a light chain variable region comprising a VLCDR1 comprising the amino acid sequence KSSQSVDYDGDSSMN (SEQ ID NO:
32), a VLCDR2 comprising the amino acid sequence AASTLES (SEQ ID NO:
33) and a VLCDR3 comprising the amino acid sequence QQTNEDPPT (SEQ ID NO:
34);
(b)
a heavy chain variable region comprising a VHCDR1 comprising the amino acid sequence GFTFSSY (SEQ ID NO:
49), a VHCDR2 comprising the amino acid sequence SSGGGQTY (SEQ ID NO:
50), a VHCDR3 comprising the amino acid sequence HDYYEGGLYYAMDY (SEQ ID NO:
48);
and
a light chain variable region comprising a VLCDR1 comprising the amino acid sequence KSSQSVDYDGDSSMN (SEQ ID NO:
32), a VLCDR2 comprising the amino acid sequence AASTLES (SEQ ID NO:
33) and a VLCDR3 comprising the amino acid sequence QQTNEDPPT (SEQ ID NO:
34);
(c)
a heavy chain variable region comprising a VHCDR1 comprising the amino acid sequence SYTMS (SEQ ID NO:
26), a VHCDR2 comprising the amino acid sequence YISSGGGNTYY ADSVKG (SEQ ID NO:
27), a VHCDR3 comprising the amino acid sequence HDYYDGGLYYAMDY (SEQ ID NO:
28);
and
a light chain variable region comprising a VLCDR1 comprising the amino acid sequence KSSQSVDYDGDSSMN (SEQ ID NO:
22), a VLCDR2 comprising the amino acid sequence AASTLES (SEQ ID NO:
23) and a VLCDR3 comprising the amino acid sequence QQTNEDPPT (SEQ ID NO:
24);
(d)
a heavy chain variable region comprising a VHCDR1 comprising the amino acid sequence GFTFSSY (SEQ ID NO:
29), a VHCDR2 comprising the amino acid sequence SSGGGNTY (SEQ ID NO:
30), a VHCDR3 comprising the amino acid sequence HDYYDGGLYYAMDY (SEQ ID NO:
28);
and
a light chain variable region comprising a VLCDR1 comprising the amino acid sequence KSSQSVDYDGDSSMN (SEQ ID NO:
22), a VLCDR2 comprising the amino acid sequence AASTLES (SEQ ID NO:
23) and a VLCDR3 comprising the amino acid sequence QQTNEDPPT (SEQ ID NO:
24);
(e)
a heavy chain variable region comprising a VHCDR1 comprising the amino acid sequence SYTMS (SEQ ID NO:
26), a VHCDR2 comprising the amino acid sequence YISSGGGNTYYADSVKG (SEQ ID NO:
27), a VHCDR3 comprising the amino acid sequence HDYYDGGLYYAMDY (SEQ ID NO 28);
and
a light chain variable region comprising a VLCDR1 comprising the amino acid sequence KASQSVDYEGDSSMN (SEQ ID NO:
42), a VLCDR2 comprising the amino acid sequence AASTLES (SEQ ID NO:
43) and a VLCDR3 comprising the amino acid sequence QQTNEDPPT (SEQ ID NO:
44);
(f)
a heavy chain variable region comprising a VHCDR1 comprising the amino acid sequence GFTFSSY (SEQ ID NO:
29), a VHCDR2 comprising the amino acid sequence SSGGGNTY (SEQ ID NO:
30), a VHCDR3 comprising the amino acid sequence HDYYDGGLYYAMDY (SEQ ID NO:
28);
and
a light chain variable region comprising a VLCDR1 comprising the amino acid sequence KASQSVDYEGDSSMN (SEQ ID NO:
42), a VLCDR2 comprising the amino acid sequence AASTLES (SEQ ID NO:
43) and a VLCDR3 comprising the amino acid sequence QQTNEDPPT (SEQ ID NO:
44);
(g)
a heavy chain variable region comprising a VHCDR1 comprising the amino acid sequence SYTMS (SEQ ID NO:
6), a VHCDR2 comprising the amino acid sequence YISSGGGNTYYPDSVKG(SEQ ID NO:
7) and a VHCDR3 comprising the amino acid sequence HDYYDGGLYYAMDY (SEQ ID NO:
8);
and
a light chain variable region comprising a VLCDR1 comprising the amino acid sequence KASQSVDYDGDSSMN (SEQ ID NO:
2), a VLCDR2 comprising the amino acid sequence AASTLES (SEQ ID NO:
3) and a VLCDR3 comprising the amino acid sequence QQTNEDPPT (SEQ ID NO:
4);
(h)
a heavy chain variable region comprising a VHCDR1 comprising the amino acid sequence GFTFSSY (SEQ ID NO:
9), a VHCDR2 comprising the amino acid sequence SSGGGNTY (SEQ ID NO:
10) and a VHCDR3 comprising the amino acid sequence HDYYDGGLYY AMDY (SEQ ID NO:
8);
and
a light chain variable region comprising a VLCDR1 comprising the amino acid sequence KASQSVDYDGDSSMN (SEQ ID NO:
2), a VLCDR2 comprising the amino acid sequence AASTLES (SEQ ID NO:
3) and a VLCDR3 comprising the amino acid sequence QQTNEDPPT (SEQ ID NO:
4);
(i)
a heavy chain variable region comprising a VHCDR1 comprising the amino acid sequence SYTMS (SEQ ID NO:
36), a VHCDR2 comprising the amino acid sequence YISSGGGQTYYPDSVKG (SEQ ID NO:
37), a VHCDR3 comprising the amino acid HDYYDGGLYYAMDY sequence (SEQ ID NO:
38);
and
a light chain variable region comprising a VLCDR1 comprising the amino acid sequence KASQSVDYDGDSSMN (SEQ ID NO:
12), a VLCDR2 comprising the amino acid sequence AASTLES (SEQ ID NO:
13) and a VLCDR3 comprising the amino acid sequence QQTNEDPPT (SEQ ID NO:
14);
(j)
a heavy chain variable region comprising a VHCDR1 comprising the amino acid sequence GFTFSSY (SEQ ID NO:
39), a VHCDR2 comprising the amino acid sequence SSGGGQTY (SEQ ID NO:
40), a VHCDR3 comprising the amino acid HDYYDGGLYYAMDY sequence (SEQ ID NO:
38);
and
a light chain variable region comprising a VLCDR1 comprising the amino acid sequence KASQSVDYDGDSSMN (SEQ ID NO:
12), a VLCDR2 comprising the amino acid sequence AASTLES (SEQ ID NO:
13) and a VLCDR3 comprising the amino acid sequence QQTNEDPPT (SEQ ID NO:
14);
(k)
a heavy chain variable region comprising a VHCDR1 comprising the amino acid sequence SYTMS (SEQ ID NO:
46), a VHCDR2 comprising the amino acid sequence YISSGGGQTYYPDSVKG (SEQ ID NO:
47), a VHCDR3 comprising the amino acid sequence HDYYEGGLYYAMDY (SEQ ID NO:
48);
and
a light chain variable region comprising a VLCDR1 comprising the amino acid sequence KASQSVDYDGDSSMN (SEQ ID NO:
12), a VLCDR2 comprising the amino acid sequence AASTLES (SEQ ID NO:
13) and a VLCDR3 comprising the amino acid sequence QQTNEDPPT (SEQ ID NO:
14);
(l)
a heavy chain variable region comprising a VHCDR1 comprising the amino acid sequence GFTFSSY (SEQ ID NO:
49), a VHCDR2 comprising the amino acid sequence SSGGGQTY (SEQ ID NO:
50), a VHCDR3 comprising the amino acid sequence HDYYEGGLYYA.MOY (SEQ ID NO:
48);
and
a light chain variable region comprising a VLCDR1 comprising the amino acid sequence KASQSVDYDGDSSMN (SEQ ID NO:
12), a VLCDR2 comprising the amino acid sequence AASTLES (SEQ ID NO:
13) and a VLCDR3 comprising the amino acid sequence QQTNEDPPT (SEQ ID NO:
14);
(m)
a heavy chain variable region comprising a VHCDR1 comprising the amino acid sequence SYTMS (SEQ ID NO:
16), a VHCDR2 comprising the amino acid sequence YISSGGGNTYYPDSVKG (SEQ ID NO:
17), a VHCDR3 comprising the amino acid sequence HDYYDGGLYYAMDY (SEQ ID NO:
18);
and
a light chain variable region comprising a VLCDR1 comprising the amino acid sequence KSSQSVDYDGDSSMN (SEQ ID NO:
22), a VLCDR2 comprising the amino acid sequence AASTLES (SEQ ID NO:
23) and a VLCDR3 comprising the amino acid sequence QQTNEDPPT (SEQ ID NO:
24);
(n)
a heavy chain variable region comprising a VHCDR1 comprising the amino acid sequence SYTMS (SEQ ID NO:
36), a VHCDR2 comprising the amino acid sequence YISSGGGQTYYPDSVKG(SEQ ID NO:
37), a VHCDR3 comprising the amino acid HDYYDGGLYYAMDY sequence (SEQ ID NO:
38);
and
a light chain variable region comprising a VLCDR1 comprising the amino acid sequence KSSQSVDYDGDSSMN (SEQ ID NO:
22), a VLCDR2 comprising the amino acid sequence AASTLES (SEQ ID NO:
23) and a VLCDR3 comprising the amino acid sequence QQTNEDPPT (SEQ ID NO:
24);
(o)
a heavy chain variable region comprising a VHCDR1 comprising the amino acid sequence GFTFSSY (SEQ ID NO:
39), a VHCDR2 comprising the amino acid sequence SSGGGQTY (SEQ ID NO:
40), a VHCDR3 comprising the amino acid HDYYDGGLYYAMDY sequence (SEQ ID NO:
38);
and
a light chain variable region comprising a VLCDR1 comprising the amino acid sequence KSSQSVDYDGDSSMN (SEQ ID NO:
22), a VLCDR2 comprising the amino acid sequence AASTLES (SEQ ID NO:
23) and a VLCDR3 comprising the amino acid sequence QQTNEDPPT (SEQ ID NO:
24);
(p)
a heavy chain variable region comprising a VHCDR1 comprising the amino acid sequence SYTMS (SEQ ID NO:
16), a VHCDR2 comprising the amino acid sequence YISSGGGNTYYPDSVKG (SEQ ID NO:
17), a VHCDR3 comprising the amino acid sequence HDYYDGGLYY AMDY (SEQ ID NO:
18);
and
a light chain variable region comprising a VLCDR1 comprising the amino acid sequence KASQSVDYEGDSSMN (SEQ ID NO:
42), a VLCDR2 comprising the amino acid sequence AASTLES (SEQ ID NO:
43) and a VLCDR3 comprising the amino acid sequence QQTNEDPPT (SEQ ID NO:
44);
(q)
a heavy chain variable region comprising a VHCDR1 comprising the amino acid sequence SYTMS (SEQ ID NO:
36), a VHCDR2 comprising the amino acid sequence YISSGGGQTYYPDSVKG(SEQ ID NO:
37), a VHCDR3 comprising the amino acid HDYYDGGLYY AMDY sequence (SEQ ID NO:
38);
and
a light chain variable region comprising a VLCDR1 comprising the amino acid sequence KASQSVDYEGDSS11N (SEQ ID NO 42), a VLCDR2 comprising the amino acid sequence AASTLES (SEQ ID NO:
43) and a VLCDR3 comprising the amino acid sequence QQTNEDPPT (SEQ ID NO:
44);
(r)
a heavy chain variable region comprising a VHCDR1 comprising the amino acid sequence GFTFSSY (SEQ ID NO:
39), a VHCDR2 comprising the amino acid sequence SSGGGQTY (SEQ ID NO:
40), a VHCDR3 comprising the amino acid HDYYDGGLYY AMDY sequence (SEQ ID NO:
38);
and
a light chain variable region comprising a VLCDR1 comprising the amino acid sequence KASQSVDYEGDSS11N (SEQ ID NO 42), a VLCDR2 comprising the amino acid sequence AASTLES (SEQ ID NO:
43) and a VLCDR3 comprising the amino acid sequence QQTNEDPPT (SEQ ID NO:
44);
(s)
a heavy chain variable region comprising a VHCDR1 comprising the amino acid sequence SYTMS (SEQ ID NO:
46), a VHCDR2 comprising the amino acid sequence YISSGGGQTYYPDSVKG (SEQ ID NO:
47), a VHCDR3 comprising the amino acid sequence HDYYEGGLYYAMDY (SEQ ID NO:
48);
and
a light chain variable region comprising a VLCDR1 comprising the amino acid sequence KASQSVDYEGDSSMN (SEQ ID NO:
42), a VLCDR2 comprising the amino acid sequence AASTLES (SEQ ID NO:
43) and a VLCDR3 comprising the amino acid sequence QQTNEDPPT (SEQ ID NO:
44);
and
or
(t)
a heavy chain variable region comprising a VHCDR1 comprising the amino acid sequence GFTFSSY (SEQ ID NO:
49), a VHCDR2 comprising the amino acid sequence SSGGGQTY (SEQ ID NO:
50), a VHCDR3 comprising the amino acid sequence HDYYEGGLYYMIDY (SEQ ID NO:
48);
and
a light chain variable region comprising a VLCDR1 comprising the amino acid sequence KASQSVDYDYEGDSSMN (SEQ ID NO:
42), a VLCDR2 comprising the amino acid sequence AASTLES (SEQ ID NO:
43) and a VLCDR3 comprising the amino acid sequence QQTNEDPPT (SEQ ID NO:
44).

196 more elements

Dependencies are inferred from the claim text.

Facts

Application: 17/665,239Filed 4 Feb 2022 · continuation
Priority: GB 19111885 Aug 2019
Published: US 2022/0162322 A126 May 2022
Granted: 13 Oct 2026
Term ends: Not estimatedThe source records don’t support an estimate.

Classification9 codes

C07K 16/2851
Against receptors, cell surface antigens or cell surface determinants: against the lectin superfamily, e.g. CD23, CD72
A61P 37/02
Drugs for immunological or allergic disorders: immunomodulators
C07K 2317/24
Characterized by taxonomic origin: containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
C07K 2317/565
Variable region, i.e. VH and/or VL: complementarity determining region [CDR]

Family

PCT/EP2020/072051Parent of this continuation · filed 5 Aug 2020
US 2022/0162322 A1Pre-grant publication · published 26 May 2022
US 12,760,109 B2This patent

From the US filing history. Foreign family members aren’t listed.

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Abstract

An anti-BDCA-2 (CLEC4C) antigen binding molecule comprising

(a)
a heavy chain variable region comprising a VHCDR1 comprising the amino acid sequence SYTMS (SEQ ID NO:
46), a VHCDR2 comprising the amino acid sequence YISSGGGQTYYPDSVKG (SEQ ID NO:
47), a VHCDR3 comprising the amino acid sequence HDYYEGGLYYAMDY (SEQ ID NO:
48);
and
a light chain variable region comprising a VLCDR1 comprising the amino acid sequence KSSQSVDYDGDSSMN (SEQ ID NO:
32), a VLCDR2 comprising the amino acid sequence AASTLES (SEQ ID NO:
33) and a VLCDR3 comprising the amino acid sequence QQTNEDPPT (SEQ ID NO:
34);
(b)
a heavy chain variable region comprising a VHCDR1 comprising the amino acid sequence GFTFSSY (SEQ ID NO:
49), a VHCDR2 comprising the amino acid sequence SSGGGQTY (SEQ ID NO:
50), a VHCDR3 comprising the amino acid sequence HDYYEGGLYYAMDY (SEQ ID NO:
48);
and
a light chain variable region comprising a VLCDR1 comprising the amino acid sequence KSSQSVDYDGDSSMN (SEQ ID NO:
32), a VLCDR2 comprising the amino acid sequence AASTLES (SEQ ID NO:
33) and a VLCDR3 comprising the amino acid sequence QQTNEDPPT (SEQ ID NO:
34);
(c)
a heavy chain variable region comprising a VHCDR1 comprising the amino acid sequence SYTMS (SEQ ID NO:
26), a VHCDR2 comprising the amino acid sequence YISSGGGNTYY ADSVKG (SEQ ID NO:
27), a VHCDR3 comprising the amino acid sequence HDYYDGGLYYAMDY (SEQ ID NO:
28);
and
a light chain variable region comprising a VLCDR1 comprising the amino acid sequence KSSQSVDYDGDSSMN (SEQ ID NO:
22), a VLCDR2 comprising the amino acid sequence AASTLES (SEQ ID NO:
23) and a VLCDR3 comprising the amino acid sequence QQTNEDPPT (SEQ ID NO:
24);
(d)
a heavy chain variable region comprising a VHCDR1 comprising the amino acid sequence GFTFSSY (SEQ ID NO:
29), a VHCDR2 comprising the amino acid sequence SSGGGNTY (SEQ ID NO:
30), a VHCDR3 comprising the amino acid sequence HDYYDGGLYYAMDY (SEQ ID NO:
28);
and
a light chain variable region comprising a VLCDR1 comprising the amino acid sequence KSSQSVDYDGDSSMN (SEQ ID NO:
22), a VLCDR2 comprising the amino acid sequence AASTLES (SEQ ID NO:
23) and a VLCDR3 comprising the amino acid sequence QQTNEDPPT (SEQ ID NO:
24);
(e)
a heavy chain variable region comprising a VHCDR1 comprising the amino acid sequence SYTMS (SEQ ID NO:
26), a VHCDR2 comprising the amino acid sequence YISSGGGNTYYADSVKG (SEQ ID NO:
27), a VHCDR3 comprising the amino acid sequence HDYYDGGLYYAMDY (SEQ ID NO 28);
and
a light chain variable region comprising a VLCDR1 comprising the amino acid sequence KASQSVDYEGDSSMN (SEQ ID NO:
42), a VLCDR2 comprising the amino acid sequence AASTLES (SEQ ID NO:
43) and a VLCDR3 comprising the amino acid sequence QQTNEDPPT (SEQ ID NO:
44);
(f)
a heavy chain variable region comprising a VHCDR1 comprising the amino acid sequence GFTFSSY (SEQ ID NO:
29), a VHCDR2 comprising the amino acid sequence SSGGGNTY (SEQ ID NO:
30), a VHCDR3 comprising the amino acid sequence HDYYDGGLYYAMDY (SEQ ID NO:
28);
and
a light chain variable region comprising a VLCDR1 comprising the amino acid sequence KASQSVDYEGDSSMN (SEQ ID NO:
42), a VLCDR2 comprising the amino acid sequence AASTLES (SEQ ID NO:
43) and a VLCDR3 comprising the amino acid sequence QQTNEDPPT (SEQ ID NO:
44);
(g)
a heavy chain variable region comprising a VHCDR1 comprising the amino acid sequence SYTMS (SEQ ID NO:
6), a VHCDR2 comprising the amino acid sequence YISSGGGNTYYPDSVKG(SEQ ID NO:
7) and a VHCDR3 comprising the amino acid sequence HDYYDGGLYYAMDY (SEQ ID NO:
8);
and
a light chain variable region comprising a VLCDR1 comprising the amino acid sequence KASQSVDYDGDSSMN (SEQ ID NO:
2), a VLCDR2 comprising the amino acid sequence AASTLES (SEQ ID NO:
3) and a VLCDR3 comprising the amino acid sequence QQTNEDPPT (SEQ ID NO:
4);
(h)
a heavy chain variable region comprising a VHCDR1 comprising the amino acid sequence GFTFSSY (SEQ ID NO:
9), a VHCDR2 comprising the amino acid sequence SSGGGNTY (SEQ ID NO:
10) and a VHCDR3 comprising the amino acid sequence HDYYDGGLYY AMDY (SEQ ID NO:
8);
and
a light chain variable region comprising a VLCDR1 comprising the amino acid sequence KASQSVDYDGDSSMN (SEQ ID NO:
2), a VLCDR2 comprising the amino acid sequence AASTLES (SEQ ID NO:
3) and a VLCDR3 comprising the amino acid sequence QQTNEDPPT (SEQ ID NO:
4);
(i)
a heavy chain variable region comprising a VHCDR1 comprising the amino acid sequence SYTMS (SEQ ID NO:
36), a VHCDR2 comprising the amino acid sequence YISSGGGQTYYPDSVKG (SEQ ID NO:
37), a VHCDR3 comprising the amino acid HDYYDGGLYYAMDY sequence (SEQ ID NO:
38);
and
a light chain variable region comprising a VLCDR1 comprising the amino acid sequence KASQSVDYDGDSSMN (SEQ ID NO:
12), a VLCDR2 comprising the amino acid sequence AASTLES (SEQ ID NO:
13) and a VLCDR3 comprising the amino acid sequence QQTNEDPPT (SEQ ID NO:
14);
(j)
a heavy chain variable region comprising a VHCDR1 comprising the amino acid sequence GFTFSSY (SEQ ID NO:
39), a VHCDR2 comprising the amino acid sequence SSGGGQTY (SEQ ID NO:
40), a VHCDR3 comprising the amino acid HDYYDGGLYYAMDY sequence (SEQ ID NO:
38);
and
a light chain variable region comprising a VLCDR1 comprising the amino acid sequence KASQSVDYDGDSSMN (SEQ ID NO:
12), a VLCDR2 comprising the amino acid sequence AASTLES (SEQ ID NO:
13) and a VLCDR3 comprising the amino acid sequence QQTNEDPPT (SEQ ID NO:
14);
(k)
a heavy chain variable region comprising a VHCDR1 comprising the amino acid sequence SYTMS (SEQ ID NO:
46), a VHCDR2 comprising the amino acid sequence YISSGGGQTYYPDSVKG (SEQ ID NO:
47), a VHCDR3 comprising the amino acid sequence HDYYEGGLYYAMDY (SEQ ID NO:
48);
and
a light chain variable region comprising a VLCDR1 comprising the amino acid sequence KASQSVDYDGDSSMN (SEQ ID NO:
12), a VLCDR2 comprising the amino acid sequence AASTLES (SEQ ID NO:
13) and a VLCDR3 comprising the amino acid sequence QQTNEDPPT (SEQ ID NO:
14);
(l)
a heavy chain variable region comprising a VHCDR1 comprising the amino acid sequence GFTFSSY (SEQ ID NO:
49), a VHCDR2 comprising the amino acid sequence SSGGGQTY (SEQ ID NO:
50), a VHCDR3 comprising the amino acid sequence HDYYEGGLYYA.MOY (SEQ ID NO:
48);
and
a light chain variable region comprising a VLCDR1 comprising the amino acid sequence KASQSVDYDGDSSMN (SEQ ID NO:
12), a VLCDR2 comprising the amino acid sequence AASTLES (SEQ ID NO:
13) and a VLCDR3 comprising the amino acid sequence QQTNEDPPT (SEQ ID NO:
14);
(m)
a heavy chain variable region comprising a VHCDR1 comprising the amino acid sequence SYTMS (SEQ ID NO:
16), a VHCDR2 comprising the amino acid sequence YISSGGGNTYYPDSVKG (SEQ ID NO:
17), a VHCDR3 comprising the amino acid sequence HDYYDGGLYYAMDY (SEQ ID NO:
18);
and
a light chain variable region comprising a VLCDR1 comprising the amino acid sequence KSSQSVDYDGDSSMN (SEQ ID NO:
22), a VLCDR2 comprising the amino acid sequence AASTLES (SEQ ID NO:
23) and a VLCDR3 comprising the amino acid sequence QQTNEDPPT (SEQ ID NO:
24);
(n)
a heavy chain variable region comprising a VHCDR1 comprising the amino acid sequence SYTMS (SEQ ID NO:
36), a VHCDR2 comprising the amino acid sequence YISSGGGQTYYPDSVKG(SEQ ID NO:
37), a VHCDR3 comprising the amino acid HDYYDGGLYYAMDY sequence (SEQ ID NO:
38);
and
a light chain variable region comprising a VLCDR1 comprising the amino acid sequence KSSQSVDYDGDSSMN (SEQ ID NO:
22), a VLCDR2 comprising the amino acid sequence AASTLES (SEQ ID NO:
23) and a VLCDR3 comprising the amino acid sequence QQTNEDPPT (SEQ ID NO:
24);
(o)
a heavy chain variable region comprising a VHCDR1 comprising the amino acid sequence GFTFSSY (SEQ ID NO:
39), a VHCDR2 comprising the amino acid sequence SSGGGQTY (SEQ ID NO:
40), a VHCDR3 comprising the amino acid HDYYDGGLYYAMDY sequence (SEQ ID NO:
38);
and
a light chain variable region comprising a VLCDR1 comprising the amino acid sequence KSSQSVDYDGDSSMN (SEQ ID NO:
22), a VLCDR2 comprising the amino acid sequence AASTLES (SEQ ID NO:
23) and a VLCDR3 comprising the amino acid sequence QQTNEDPPT (SEQ ID NO:
24);
(p)
a heavy chain variable region comprising a VHCDR1 comprising the amino acid sequence SYTMS (SEQ ID NO:
16), a VHCDR2 comprising the amino acid sequence YISSGGGNTYYPDSVKG (SEQ ID NO:
17), a VHCDR3 comprising the amino acid sequence HDYYDGGLYY AMDY (SEQ ID NO:
18);
and
a light chain variable region comprising a VLCDR1 comprising the amino acid sequence KASQSVDYEGDSSMN (SEQ ID NO:
42), a VLCDR2 comprising the amino acid sequence AASTLES (SEQ ID NO:
43) and a VLCDR3 comprising the amino acid sequence QQTNEDPPT (SEQ ID NO:
44);
(q)
a heavy chain variable region comprising a VHCDR1 comprising the amino acid sequence SYTMS (SEQ ID NO:
36), a VHCDR2 comprising the amino acid sequence YISSGGGQTYYPDSVKG(SEQ ID NO:
37), a VHCDR3 comprising the amino acid HDYYDGGLYY AMDY sequence (SEQ ID NO:
38);
and
a light chain variable region comprising a VLCDR1 comprising the amino acid sequence KASQSVDYEGDSS11N (SEQ ID NO 42), a VLCDR2 comprising the amino acid sequence AASTLES (SEQ ID NO:
43) and a VLCDR3 comprising the amino acid sequence QQTNEDPPT (SEQ ID NO:
44);
(r)
a heavy chain variable region comprising a VHCDR1 comprising the amino acid sequence GFTFSSY (SEQ ID NO:
39), a VHCDR2 comprising the amino acid sequence SSGGGQTY (SEQ ID NO:
40), a VHCDR3 comprising the amino acid HDYYDGGLYY AMDY sequence (SEQ ID NO:
38);
and
a light chain variable region comprising a VLCDR1 comprising the amino acid sequence KASQSVDYEGDSS11N (SEQ ID NO 42), a VLCDR2 comprising the amino acid sequence AASTLES (SEQ ID NO:
43) and a VLCDR3 comprising the amino acid sequence QQTNEDPPT (SEQ ID NO:
44);
(s)
a heavy chain variable region comprising a VHCDR1 comprising the amino acid sequence SYTMS (SEQ ID NO:
46), a VHCDR2 comprising the amino acid sequence YISSGGGQTYYPDSVKG (SEQ ID NO:
47), a VHCDR3 comprising the amino acid sequence HDYYEGGLYYAMDY (SEQ ID NO:
48);
and
a light chain variable region comprising a VLCDR1 comprising the amino acid sequence KASQSVDYEGDSSMN (SEQ ID NO:
42), a VLCDR2 comprising the amino acid sequence AASTLES (SEQ ID NO:
43) and a VLCDR3 comprising the amino acid sequence QQTNEDPPT (SEQ ID NO:
44);
and
or
(t)
a heavy chain variable region comprising a VHCDR1 comprising the amino acid sequence GFTFSSY (SEQ ID NO:
49), a VHCDR2 comprising the amino acid sequence SSGGGQTY (SEQ ID NO:
50), a VHCDR3 comprising the amino acid sequence HDYYEGGLYYMIDY (SEQ ID NO:
48);
and
a light chain variable region comprising a VLCDR1 comprising the amino acid sequence KASQSVDYDYEGDSSMN (SEQ ID NO:
42), a VLCDR2 comprising the amino acid sequence AASTLES (SEQ ID NO:
43) and a VLCDR3 comprising the amino acid sequence QQTNEDPPT (SEQ ID NO:
44).

196 more elements

Facts

Application

17/665,239Filed 4 Feb 2022 · continuation

Priority

GB 19111885 Aug 2019

Published

US 2022/0162322 A126 May 2022

Granted

13 Oct 2026

Term ends

Not estimatedThe source records don’t support an estimate.

Classification9 codes

C07K 16/2851
Against receptors, cell surface antigens or cell surface determinants: against the lectin superfamily, e.g. CD23, CD72
A61P 37/02
Drugs for immunological or allergic disorders: immunomodulators
C07K 2317/24
Characterized by taxonomic origin: containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
C07K 2317/565
Variable region, i.e. VH and/or VL: complementarity determining region [CDR]