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US 12,760,107 B2Granted
Feline antibody variants
AssigneeZoetis Services LLC
InventorsLisa Marie Bergeron, Henry Luis Campos
Life of this patent
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Abstract
The invention relates generally to feline antibody variants and uses thereof. Specifically, the invention relates to mutations in the constant region of feline antibody for improving its half-life and other characters.
Claims14
A method for increasing the serum half-life of a feline IgG in a cat, the method comprising:
- administering to said cat the feline IgG comprising a mutant feline IgG constant domain and a feline IgG variable domain,
- wherein the mutant feline IgG constant domain comprises an amino acid substitution relative to a wild-type feline IgG constant domain, wherein said substitution is at amino acid residue 428, numbered according to the EU index as in Kabat,
- wherein said substitution is a substitution of serine at position 428 with leucine, and wherein amino acid residues at positions 434, 436, 438, 440, 259, and 308 have wildtype residues serine, histidine, glutamine, serine, valine, and isoleucine, respectively,
- thereby increasing the serum half-life of the feline IgG in said cat.
1 more element
A feline IgG comprising:
- a mutant feline IgG constant domain and a feline IgG variable domain,
- wherein the mutant feline IgG constant domain comprises an amino acid substitution relative to a wild-type feline IgG constant domain, wherein said substitution is at amino acid residue 428, numbered according to the EU index as in Kabat,
- wherein said substitution is a substitution of serine at position 428 with leucine,
- wherein amino acid residues at positions 434, 436, 438, 440, 259, and 308 have wildtype residues serine, histidine, glutamine, serine, valine, and isoleucine, respectively, and
- wherein the presence of said substitution in said constant domain increases the serum half-life of the feline IgG in a cat.
2 more elements
Dependencies are inferred from the claim text.