Humanized CD19 antibody and use thereof
AssigneeHainan Simcere Zaiming Pharmaceutical Co., Ltd.
InventorsHu Ge, Lian Xin
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Abstract
The present invention discloses a humanized CD19 antibody and use thereof, in particular discloses an antibody or an antigen-binding fragment capable of binding to CD19, a multispecific antigen-binding molecule, a chimeric antigen receptor, an immune effector cell, a nucleic acid fragment, a vector, a cell, a composition, a preparation method, pharmaceutical use and a treatment method for cancer and an autoimmune disease, which are of great significance for the treatment of the cancer and the autoimmune disease.
Claims11
A humanized antibody or antigen-binding fragment specifically binding to CD19, wherein the humanized antibody or the antigen-binding fragment comprises a heavy chain variable region set forth in SEQ ID NO:
- 8 and a light chain variable region set forth in SEQ ID NO:
- 7.
Dependencies are inferred from the claim text.