Nanoscale polymeric micellar scaffolds for rapid and efficient antibody production
AssigneeIowa State University Research Foundation, Inc.
InventorsSurya Mallapragada, Michael Wannemuehler, Balaji Narasimhan, Sujata Senapati
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Abstract
Compositions and methods are provided for rapid and efficient production of antibodies invitro as well as in vivo, which may be used to neutralize antigens. More specifically, the present invention relates to scaffolds comprised of amphiphilic multiblock copolymers that can form micelles based on nonionic or amphiphilic core blocks as well as ionic blocks, and with an antigen and methods of crosslinking B cell receptors to specifically produce antibodies against the antigen in vitro as well as in vivo in a more efficient method than other available monoclonal antibody production method.
Claims25
A nanoscale scaffold composition for in vitro antibody production comprising:
- a multiblock copolymer comprising an amphiphilic block and an ionic block which forms micelles in aqueous solutions;
- an antigen or fragment thereof, wherein said antigen is SARS-CoV-2 virus;
- and
- a population of B cells.
Dependencies are inferred from the claim text.