Modified T cells and methods of preparing the same
AssigneeThe University of North Carolina at Chapel Hill
InventorsGianpietro Dotti, Yang Xu, Xingcong Ma
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Abstract
Disclosed herein are modified T cells comprising an IL12β p40 subunit. Also disclosed herein are methods of increasing T cell proliferation and/or methods of treating cancer by administering the modified T cells comprising an IL12β p40 subunit.
Claims17
A modified chimeric antigen receptor (CAR) T cell comprising a cytokine, wherein the cytokine consists of an IL-12β p40 subunit , wherein the T cell, upon activation, produces IL-23.
A method of increasing CAR T cell proliferation comprising modifying a T cell to comprise a cytokine, wherein the cytokine consists of an IL12β p40 subunit.
A method of treating cancer comprising administering to a subject a modified CAR T cell comprising a cytokine, wherein the cytokine consists of an IL-12β p40 subunit.
Dependencies are inferred from the claim text.