Multivalent particles compositions and methods of use

A multivalent particle comprising a fusion protein that comprises a mammalian polypeptide and a transmembrane polypeptide, wherein the fusion protein is displayed in an oligomeric format and expressed at least 10 copies on a surface of the multivalent particle, wherein the mammalian polypeptide binds to a viral protein and comprises an amino acid sequence having at least 90% sequence identity to the amino acid sequence according to SEQ ID NO:

• 2, and wherein the transmembrane polypeptide comprises an amino acid sequence having at least 90% sequence identity to amino acids 1-594 of SEQ ID NO:
• 31.