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US 12,760,069 B2Granted
Compounds targeting ALPHA4-BETA7 integrin
AssigneeZealand Pharma A/S
InventorsAndrew Roughton, Narendrakumar Patel, Adam Paul Kafal, Manuel Perez Vazquez, Jennifer Hickey, Sai Kumar Chakka, Monzur Morshed
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Abstract
Compounds of formula (I) and pharmaceutically acceptable salts and solvates thereof, are described. The compounds are α4β7 antagonists and are useful in the prevention or treatment of inflammatory conditions and/or autoimmune diseases, especially inflammatory bowel disease.
Claims18
A compound of formula (I):
- or a pharmaceutically acceptable salt or solvate thereof, wherein the stereochemistry of the carbon atom at each of positions 1a, 1b, 2a, 2b, 3a, 3b, 4a, 4b, 5a, 5b, 6a, 6b, 7a and 7b may each be independently (R) or (S).
Dependencies are inferred from the claim text.