Bivalent antagonists of inhibitors of apoptosis proteins

A compound of Formula I, or a pharmaceutically acceptable salt of the compound:

• wherein
• X is O or CH2;
• q is 0, 1
• R1 is selected from an unsubstituted C1-6 alkyl, C3-6 cycloalkyl, or heterocycylalkyl group;
• R2 is an unsubstituted C1-6 alkyl;
• R3 and R4 at each occurrence are independently H, an amino-protecting group, or an unsubstituted C1-6 alkyl group;
• R5 at each occurrence is independently H, —OH, or O-(hydroxyl protecting group);
• and
• Linker is a divalent moiety selected from a bond, an oxy moiety, an amino moiety,
• wherein:
• m is 0, 1, 2, 3, or 4;
• and
• n is 1 or 2.