Beta-strand bridge peptide
AssigneesXeno-Interface Inc., Kyoto University
InventorsKazuhiro Hayashi, Michiyuki Matsuda
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Abstract
The present disclosure provides a novel bridge peptide. The present disclosure provides a bridge peptide comprising a bridge moiety and a peptide moiety, wherein position β is tertiary or quaternary when the carbon at which the bridge moiety attaches to the peptide moiety is in position α. The present disclosure provides a novel bridge peptide, particularly a bridge peptide resulting from stably bridging a peptide that does not possess a hydrogen bond to induce or maintain a secondary structure, e.g., a peptide having a β-strand structure.
Claims15
A bridge peptide, comprising a bridge moiety and a peptide moiety, wherein:
- the bridge moiety attaches to position α of the peptide moiety;
- a position β of the peptide moiety is tertiary or quaternary;
- and
- the bridge peptide has a crosslink formed by a crosslinking method selected from the group consisting of olefin metathesis, alkyne metathesis, click chemistry, reductive amination, Michael addition, and carbamate formation.
Dependencies are inferred from the claim text.