Synthetic triterpenoids with nitrogen-based substituents at C-17 and methods of use thereof

A compound of the formula:

• wherein:
• R1 is hydrogen;
• or
• alkyl(C≤8) or substituted alkyl(C≤8)
• or
• R1 and R2 are taken together as defined below;
• R2 is alkyl(C≤8) or substituted alkyl(C≤8);
• or
• —C(O) R5, wherein:
• R5 is hydrogen;
• or
• alkyl(C≤8), alkenyl(C≤8), alkynyl(C≤8), alkylamino(C≤8), dialkylamino(C≤8), cycloalkyl(C≤8), cycloalkoxy(C≤8), cycloalkylamino(C≤8), heterocycloalkyl(C≤8), or a substituted version of any one of these groups;
• or
• R2 and R1 are taken together as defined below;
• R1 and R2, when taken together with the nitrogen atom of the —NR1R2 group, is N-heteroaryl(C≤8), substituted N-heteroaryl(C≤8), N-heterocycloalkyl(C≤8), substituted N-heterocycloalkyl(C≤8), or
• 3-oxo-1-(t-butoxycarbonyl) pyrazolidin-2-yl;
• R3 and R3′ are each independently hydrogen, alkyl(C≤8), or substituted alkyl(C≤8);
• and
• R6 is hydrogen or hydroxy;
• or a pharmaceutically acceptable salt thereof.