# US 12,760,058 B2 · Prodrugs of neuroactive steroids

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- Number: US 12,760,058 B2
- Document ID: US12760058B2
- Status: Granted
- Kind: B2
- Application number: 17/801,894
- Filed: 2021-03-01
- Published: 2023-12-28
- Granted: 2026-10-13
- Earliest claimed: 2020-02-27
- Assignees: Brii Biosciences, Inc.
- Applicants: Brii Biosciences, Inc.
- Inventors: Lianhong Xu
- Web page: https://patentgrep.com/patent/US12760058B2

## CPC

- C07J 7/009: {by only one oxygen atom doubly bound}
- C07J: STEROIDS (seco-steroids C07C)

## Abstract

The present application relates to novel compounds that are prodrugs of brexanolone, ganaxolone and zuranolone, pharmaceutical compositions comprising one or more compounds disclosed herein and salts thereof, and a pharmaceutically acceptable excipient, and use of the compounds disclosed herein and salts thereof for treating diseases or conditions related to GABAA receptor function, such as major depression disorder (MDD) and postpartum depression (PPD), in mammals and especially in humans.

## Claims

### Claim 1

A compound having the structure:
or a pharmaceutically acceptable salt thereof.

### Claim 2 (depends on 1)

A pharmaceutical composition comprising the compound or pharmaceutically acceptable salt thereof of claim 1 and at least one pharmaceutically acceptable excipient.

### Claim 3 (depends on 1)

The compound of claim 1, wherein the compound is:
or a pharmaceutically acceptable salt thereof.