Compounds having inhibitory activity on prostaglandin E2 receptor and uses thereof

A compound of formula IA-3, or a solvate, stereoisomer or pharmaceutically acceptable salt thereof:

• in which,
• R1 is selected from the group consisting of hydrogen, halogen, hydroxy, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 haloalkyl, and C1-C6 haloalkoxy;
• R2 is selected from the group consisting of hydrogen, halogen, hydroxy, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 haloalkyl, C1-C6 haloalkoxy, C3-C8 cycloalkyl, and phenyl;
• and
• R3 is
• W is —(CH2)o—, —(CH2)o—C≡C—, —C(O)—, —O—, —NH—, or —N(C1-C6 alkyl)-, wherein H of said CH2 may be optionally substituted with one or more halogen, hydroxy, or C1-C6 alkoxy;
• Cy is selected from the group consisting of C6-C10 aryl, 45- to 10-membered monocyclic or bicyclic heteroaryl containing 1 or 2 nitrogen atoms, and 4- to 7-membered heterocycloalkyl containing 1 or 2 nitrogen atoms, the heterocycloalkyl being a monocyclic or bicyclic, saturated or partially unsaturated ring system which may be spiro, bridged or fused, and Cy may be optionally substituted with one or more R′;
• Ra is hydrogen, halogen, C1-C6 alkyl, C1-C6 haloalkyl, or —V-Cy2,
• wherein V is absent, —CH2—, or —O—,
• Cy2 is selected from the group consisting of C6-C10 aryl, 45- to 10-membered monocyclic or bicyclic heteroaryl containing 1 or 2 heteroatoms selected from N or O, 4- to 7-membered heterocycloalkyl containing 1 or 2 heteroatoms selected from N or O, C3-C8 cycloalkyl and C3-C8 cycloalkenyl, the heterocycloalkyl being a monocyclic or bicyclic, saturated or partially unsaturated ring system which may be spiro, bridged or fused, and Cy2 may be optionally substituted with one or more R″;
• R′ is each independently selected from the group consisting of halogen, amino, C1-C6 alkyl, and C1-C6 haloalkyl;
• R″ is selected from the group consisting of halogen, hydroxy, cyano, amino, oxo, C1-C6 alkyl, C1-C6 alkoxy, —S—(C1-C6 alkyl), —SO2—(C1-C6 alkyl), —CO—(C1-C6 alkyl), —C(O)H, —COO—(C1-C6 alkyl), —COOH, —CONH2, —CONH—(C1-C6 alkyl), —CON(C1-C6 alkyl)2, —(CH2)p—NH2, —(CH2)p—NH—(C1-C6 alkyl), —(CH2)p—N(C1-C6 alkyl)2, —(CH2)p—NH—CO—(C1-C6 alkyl), —(CH2)p—NH—COO—(C1-C6 alkyl), —(CH2)p—OH, 3- to 7-membered heterocycloalkyl containing 1 heteroatom selected from N, O and S, C3-C8 cycloalkyl, and —(CH2)p—(C3-C8 cycloalkyl), the heterocycloalkyl being a monocyclic or bicyclic, saturated or partially unsaturated ring system which may be spiro, bridged or fused, wherein said C1-C6 alkyl and C1-C6 alkoxy may be optionally substituted with one or more halogen, hydroxy, cyano or amino, and said 3- to 7-membered heterocycloalkyl and C3-C8 cycloalkyl may be optionally substituted with one or more halogen, hydroxy, cyano, oxo or amino;
• R4 is hydrogen, or C1-C6 alkyl;
• R8 is —C(═O)R8′ and R8′ is hydroxy or C1-C6 alkoxy;
• o is an integer of 1 or 2;
• and
• p is an integer of 0, 1 or 2.