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US 12,760,029 B2Granted
KRAS G12D inhibitors
AssigneeBristol-Myers Squibb Company
InventorsBrian Edward Fink, Robert Joseph Cherney, Khehyong Ngu, Upender Velaparthi, Wayne David Vaccaro, Zheming Ruan, Lan-Ying Qin, Pravin S. Shirude, Hasibur Rahaman
Life of this patent
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Abstract
The present disclosure relates to KRAS inhibitors. Methods of treating cancers using the compounds are also provided.
Claims10
A compound of formula (I):
- or a pharmaceutically acceptable salt thereof;
- wherein:
- R1 is aryl or heteroaryl, wherein the aryl and the heteroaryl are optionally substituted with one, two, three, four, or five substituents independently selected from C1-C3alkyl, C2-C4alkenyl, C2-C4alkynyl, amino, aminoC1-C3alkyl, C3-C4cycloalkyl, halo, haloC1-C3alkyl, hydroxy, and hydroxyC1-C3alkyl;
- R2 and R3 are independently selected from hydrogen, C1-C3alkoxy, C1-C3alkyl, cyano, halo, haloC1-C3alkyl, and hydroxy;
- R4 is selected from:
- wherein
- Ra is hydrogen or C1-C3alkyl;
- and
- denotes the point of attachment to the parent molecular moiety;
- R5 is selected from
- wherein q, r, and d are each independently 0 or 1;
- and wherein Rx, Ry, and Rp are independently selected from C1-C3alkoxy, C1-C3alkyl, halo, haloC1-C3alkyl, and hydroxy.
9 more elements
A compound selected from:
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.