Pyrrolidine derivatives as DDRs inhibitors
AssigneeChiesi Farmaceutici S.p.A.
InventorsLaura Carzaniga, Fabio Rancati, Andrea Rizzi, Eleonora Ghidini, Nicolò Iotti, Roberta Mazzucato, Stefano Levanto, Ben Paul Whittaker
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Abstract
The present invention relates to compounds of formula (I) inhibiting Discoidin Domain Receptors (DDR inhibitors), methods of preparing such compounds, intermediate compounds useful in such preparations, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful for instance in the treatment of many disorders associated with DDR mechanisms.
Claims17
A compound of formula (I)
- wherein
- Y is absent or is —C(O)—;
- R1 is —(C1-C6)alkylene-NRARB or hydrogen;
- R3 is —(C1-C4)alkyl;
- A is selected from the group consisting of A1, A2, A3
- and bicyclic heteroaryl B,
- wherein * indicates the point of attachment to Y and B is substituted by R2;
- wherein
- R2 is H or selected from the group consisting of halogen, cyano, —NRARB, —C(O)NRARB, —C(O)NRC—(C1-C6)alkylene-NRARB, —C(O)NRC—(C1-C6)alkylene-ORA, —NRAC(O)RB, —ORA, —NRC—(C1-C6)alkylene-ORA, —NRC—(C1-C6)alkylene-NRARB, —C(O)NRA-heterocycloalkyl, heterocycloalkyl, —NRA-heteroaryl, —(C1-C6)alkylene-heterocycloalkyl, —(C1-C6)alkylene-ORA, —O—(C1-C6)alkylene-NRARB, —O—(C1-C6)alkylene-ORA, —O—(C1-C6)alkylene-heterocycloalkyl, —(C1-C6) haloalkyl and —(C1-C6)alkyl;
- RA, RB and RC are independently —(C1-C6)alkyl or hydrogen;
- or RA and RB taken together with the nitrogen they are attached to may form a heterocycloalkyl;
- and wherein each heterocycloalkyl or heteroaryl of R2 is substituted by one or more substituents independently selected from the group consisting of hydrogen, halogen, —(C1-C6)alkyl, —(C1-C6) haloalkyl, —(C1-C6)alkylene-ORA, —ORA, —O—(C1-C6)alkylene-NRARB and —O—(C1-C6)alkylene-ORA;
- or a pharmaceutically acceptable salt of said compound.
A compound selected from the group consisting of the compound of formula (VI)
- and the compound of formula (VII)
- wherein
- R1 is —(C1-C6)alkylene-NRARB or hydrogen;
- R3 is —(C1-C4)alkyl;
- RA, and RB are independently —(C1-C6)alkyl or hydrogen;
- or RA and RB taken together with the nitrogen they are attached to may form a heterocycloalkyl.
Dependencies are inferred from the claim text.