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US 12,760,003 B2Granted
Modulators of BCL6 proteolysis and associated methods of use
AssigneeArvinas Operations, Inc.
InventorDan Sherman
Life of this patent
Estimating the term…
Abstract
This disclosure pertains to bifunctional compounds, the preparation thereof, and the use of these bifunctional compounds in the treatment of diseases or disorders that result from aggregation or accumulation of B-cell lymphoma 6 protein, in subjects in need thereof.
Claims11
A bifunctional compound of Formula (I):
- or a pharmaceutically acceptable salt thereof, wherein:
- R1 is H or C1-C6 alkyl;
- Q is
- X is N or CH;
- Y1, Y2, and Y3 are each, independently, N or CR3;
- Z1 and Z2 are each, independently, N or CH;
- R2 is H or C1-C6 alkyl;
- each R3 is, independently, H, halogen, C1-C6 alkyl, C1-C6 haloalkyl, —O—(C1-C6 alkyl), —O—(C1-C6 haloalkyl);
- of the Q indicates the point of attachment with the X or the glutarimide.
6 more elements
A bifunctional compound of Formula (I:
- wherein:
- R1 is H or C1-C6 alkyl;
- Q is
- X is N or CH;
- Y1, Y2, and Y3 are each, independently, N or CR3;
- Z1 and Z2 are each, independently, N or CH;
- R2 is H or C1-C6 alkyl;
- each R3 is, independently, H, halogen, C1-C6 alkyl, C1-C6 haloalkyl, —O—(C1-C6 alkyl), or —O—(C1-C6 haloalkyl);
- of the Q indicates the point of attachment with the X or the glutarimide.
6 more elements
A bifunctional compound that is selected from the group consisting of,
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.