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US 12,760,002 B2Granted
Indazole derivative and use thereof
AssigneeKorea Research Institute of Chemical Technology
InventorsPil Ho Kim, Seong Hwan Kim
Life of this patent
Estimating the term…
Abstract
Indazole derivatives, and use thereof, wherein the indazole derivatives have TRIB2 or YAP inhibitory activity, and can be effectively used as a pharmaceutical composition for treating cancer, narcolepsy, and fasciitis.
Claims12
A compound represented by Chemical Formula 1 below, an optical isomer thereof, or a acceptable salt thereof:
- wherein,
- R1 is a substituted or unsubstituted tetrahydroisoquinoline,
- wherein the substituted tetrahydroisoquinoline has as a substituent at least one selected from the group consisting of a hydrogen atom, a C1-C4 alkyl, halogen, —NH2, —OH, Boc(tert-butoxycarbonyl), C(═O)NH2, C(═O)CF3,
- R2 is a substituent selected from the group consisting of a hydrogen atom, a C1-C6 alkyl, acetyl, trifluoroacetyl, Boc(tert-butoxycarbonyl),
- and
- R3 is a substituted or unsubstituted C4-C12 aryl, a substituted or unsubstituted C4-C12 heteroaryl, a substituted or unsubstituted C4-C12 heterocycloalkyl, or a substituted or unsubstituted pyridine,
- wherein the substituted C4-C12 aryl, C4-C12 heteroaryl, C4-C12 heterocycloalkyl, or pyridine has as a substituent at least one selected from the group consisting of a hydrogen atom, halogen, a C1-C6 alkyl, a C4-C6 heterocycloalkyl, a C1-C4 alkyl C4-C6 heterocycloalkyl, a C1-C4 alkyl C4-C6 aryl, and
4 more elements
A compound represented by Chemical Formula 2 below, an optical isomer thereof, or a pharmaceutically acceptable salt thereof:
- wherein,
- R2 is a substituent selected from the group consisting of a hydrogen atom, a C1-C6 alkyl, acetyl, trifluoroacetyl, Boc(tert-butoxycarbonyl), and
- R3 is a substituted or unsubstituted C4-C12 aryl, a substituted or unsubstituted C4-C12 heteroaryl, a substituted or unsubstituted C4-C12 heterocycloalkyl, or a substituted or unsubstituted pyridine,
- wherein the substituted C4-C12 aryl, C4-C12 heteroaryl, C4-C12 heterocycloalkyl, or pyridine has as a substituent at least one selected from the group consisting of a hydrogen atom, halogen, a C1-C6 alkyl, a C4-C6 heterocycloalkyl, a C1-C4 alkyl C4-C6 heterocycloalkyl, a C1-C4 alkyl C4-C6 aryl, or
- R4 is a substituent selected from the group consisting of a hydrogen atom, a C1-C6 alkyl, acetyl, and trihaloacetyl;
- R5 are each independently a substituent selected from the group consisting of a hydrogen atom, hydroxy, halogen, and a C1-C6 alkyl;
- R6 are each independently a substituent selected from the group consisting of a hydrogen atom, hydroxy, nitro, amino, halogen, a C1-C4 alkyl, and a C1-C4 alkoxy;
- and
- n is an integer of 0, 1, or 2.
6 more elements
Dependencies are inferred from the claim text.