Back to results
US 12,759,999 B2Granted
Indole carboxamide compounds
AssigneeBristol-Myers Squibb Company
InventorsQingjie Liu, Scott Hunter Watterson, John E. Macor, Khehyong Ngu, Saleem Ahmad
Life of this patent
Estimating the term…
Abstract
Disclosed are compounds of Formula (I): or a salt thereof, wherein: X is CR4 or N; R1, R2, R3, R4, and A are defined herein. Also disclosed are methods of using such compounds as inhibitors of Bruton's tyrosine kinase (Btk), and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.
Claims12
A compound of Formula (I):
- wherein:
- X is CR4;
- A is:
- Q2 is —CN, —C(O) (C1-4 alkyl substituted with zero or 1 R11), —C(O)(C3-6 cycloalkyl substituted with zero or 1 R11), —C(O)(C5-6 cycloalkenyl), —C(O)CR10═CR10R10, —C(O)C(R10)═CHCH2N(CH3)2, —C(O)C═CR7, —C(O)C═C(C1-3 hydroxyalkyl), —C(O)C═C(phenyl), —C(O)C═CSi(CH3)3, or —S(O)2CH═CHR10;
- R1 is H, —CH3, —CF3, or phenyl substituted with zero or 1 R12;
- R2 is H, —CH3, cyclopropyl, or phenyl substituted with zero or 1 R12, provided that zero or one of R1 and R2 is phenyl substituted with zero or 1 R12;
- R3 is F, Cl, or I;
- R4 is H, F, —OH, or —OCH3;
- each R7 is H, C1-4 alkyl, or cyclopropyl;
- R10, at each occurrence, is independently H or —CH3;
- R11 is F, Cl, —CN, —CF3, or C1-3 alkoxy;
- and
- R12 is F, Cl, —CN, —CF3, or C1-3 alkoxy.
10 more elements
Dependencies are inferred from the claim text.