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US 12,759,995 B2Granted
Inhibitors of RNA-binding proteins, compositions thereof, and therapeutic uses therof
AssigneesUniversity of North Carolina, University of Kansas
InventorsJeff Aube, Sudeshna Roy, Liang Xu, Xiaoqing Wu, Lan Lan
Life of this patent
Estimating the term…
Abstract
The present technology is directed to compounds that inhibit of the interaction of RNA-binding proteins with RNA, intermediates thereof, compositions thereof, and methods of treatment utilizing such compounds, where the compounds are of Formula I, where Z1 is aryl, heteroaryl, cycloalkyl; L′ is absent, —CH2—, —CH2—CH2—, or —CH≡CH—; X1 is O, NH, or S; and X2 is OH, NH2, NH—OH, NH—NH2, or O—(C1-C6 alkyl).
Claims19
A compound according to Formula I
- or a pharmaceutically acceptable salt thereof, wherein
- Z1 is
- R1, R2, R3, R4, and R5 are each independently H, halo, —NR75R76, cyano, trifluoromethyl, thiol, alkylthio, sulfoxide, sulfone, nitro, pentafluorosulfanyl, carboxylate, amide, ester, C1-C6 alkyl, C1-C6 alkoxy, aryl, aryloxy, C1-C6 alkanoyl, C1-C8 alkanoyloxy, aryloyl, or aryloyloxy group, where any two adjacent R1, R2, R3, R4, and R5 may join to form a 5-membered alkyl, heteroalkyl, aryl, or heteroaryl;
- R75 and R76 are each independently alkenyl, alkynyl, cycloalkyl, aryl, aralkyl, heterocyclylalkyl, heterocyclyl, or unsubstituted alkyl;
- L′ is —CH2—, —CH2—CH2—, or —CH═CH—;
- X1 is O, NH, or S;
- and
- X2 is OH, NH2, NH—OH, NH—NH2, or O—(C1-C6 alkyl).
5 more elements
A compound according to Formula IA
- or a pharmaceutically acceptable salt thereof, wherein
- R2 is tert-butyl;
- R1, R3, R4, and R5 are each independently H;
- L1 is absent;
- X1 is O, NH, or S;
- and
- X2 is NH2, NH—OH, or NH—NH2.
4 more elements
Dependencies are inferred from the claim text.