# US 12,759,987 B2 · Cardiac therapeutic

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- Number: US 12,759,987 B2
- Document ID: US12759987B2
- Status: Granted
- Kind: B2
- Application number: 17/625,421
- Filed: 2020-07-08
- Published: 2022-08-25
- Granted: 2026-10-13
- Earliest claimed: 2019-07-08
- Assignees: National University of Singapore
- Applicants: National University of Singapore
- Inventors: Chun Yong Eric Chan; Aneesh Vidyadhar Karkhanis; Gopalakrishnan Venkatesan
- Web page: https://patentgrep.com/patent/US12759987B2

## CPC

- C07D 307/80: Radicals substituted by oxygen atoms
- A61P 9/06: Antiarrhythmics
- C07B 2200/05: Isotopically modified compounds, e.g. labelled
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- C07B: GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR (preparation of carboxylic acid esters by telomerisation C07C67/47; telomerisation C08F)

## Abstract

The invention concerns a novel cardiac therapeutic effective against atrial fibrillation (AF); a pharmaceutical composition comprising same; the use of same to treat cardiac disease; and a method of treating cardiac disease involving the use of same.

## Claims

### Claim 1

A compound according to Formula (I) or a pharmaceutically acceptable salt thereof:
wherein:
R1, R2 and R3 each represents deuterium;
n represents 2 or 3;
each R4 independently represents a C1-6 hydrocarbyl group which may be substituted with one or more of nitro, halogen, amino, amido, cyano, carboxyl, sulphonyl, hydroxyl, ketone or aldehyde groups;
R5 represents hydrogen or
and
each R6 independently represents hydrogen or halogen.

### Claim 2 (depends on 1)

The compound or pharmaceutically acceptable salt according to claim 1, wherein each R4 represents a C1-6 alkyl chain.

### Claim 3 (depends on 1)

The compound or pharmaceutically acceptable salt according to claim 1, wherein R5 represents

### Claim 4 (depends on 1)

The compound or pharmaceutically acceptable salt according to claim 1, wherein each R6 represents hydrogen.

### Claim 5 (depends on 1)

The compound or pharmaceutically acceptable salt according to claim 1, wherein the compound is a compound of Formula (II):
or the pharmaceutically acceptable salt is a pharmaceutically acceptable salt of Formula (II).

### Claim 6 (depends on 1)

A pharmaceutical composition comprising the compound or pharmaceutically acceptable salt according to claim 1, and a pharmaceutically acceptable excipient or carrier.

### Claim 7 (depends on 5)

A pharmaceutical composition comprising the compound or pharmaceutically acceptable salt according to claim 5, and a pharmaceutically acceptable excipient or carrier.

### Claim 8 (depends on 1)

A method for treating a cardiac disease, the method comprising administering to a patient in need of such a treatment a therapeutically effective amount of the compound or pharmaceutically acceptable salt according to claim 1.

### Claim 9 (depends on 8)

The method according to claim 8, wherein the cardiac disease is a cardiac arrhythmia.

### Claim 10 (depends on 9)

The method according to claim 9, wherein the cardiac arrhythmia is atrial fibrillation.

### Claim 11 (depends on 5)

A method for treating a cardiac disease, the method comprising administering to a patient in need of such a treatment a therapeutically effective amount of the compound or pharmaceutically acceptable salt according to claim 5.

### Claim 12

A compound according to Formula (III) or a pharmaceutically acceptable salt thereof:
wherein each R7 represents deuterium.