Crystal forms of tetrahydro-N, N-dimethyl-2,2-diphenyl-3-furanmethanamine, processes of making such forms, and their pharmaceutical compositions
AssigneeAnavex Life Sciences Corp.
InventorsLinda Sharon Daintree, Daniel Mark Ledger, Lucy Anne Leonard, Peter York
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Abstract
Polymorphic forms of tetrahydro-N,N-dimethyl-2,2-diphenyl-3-furanmethanamine hydrochloride (ANAVEX2-73) and a metabolite of tetrahydro-N,N-dimethyl-2,2-diphenyl-3-furanmethanamine hydrochloride (ANAVEX19-144) are disclosed and characterized. Compositions and method for treatment of Alzheimer's disease that includes the polymorphic forms and metabolite of tetrahydro-N,N-dimethyl-2,2-diphenyl-3-furanmethanamine hydrochloride (ANAVEX2-73).
Claims9
A composition comprising a crystal form of tetrahydro-N,N-dimethyl-2,2-diphenyl-3-furanmethanamine hydrochloride (ANAVEX2-73) made by crystallizing ANAVEX2-73 in a supercritical fluid (SCF) environment, wherein the supercritical fluid comprises supercritical carbon dioxide;
- and wherein the crystal form is characterized by an X-ray diffraction pattern of FIG. 1, FIG. 4, or FIG. 8.
Dependencies are inferred from the claim text.