Aryl or heteroaryl derivative

A compound represented by the formula (I) or a pharmaceutically acceptable salt thereof:

• wherein,
• X1, X2, and X3 are independently CH, N, or CY;
• At least one of X1, X2, and X3 is CH or CY;
• Y is a halogen atom, or a C1-3 alkyl group optionally substituted with 1 to 3 halogen atoms;
• R1 is a cyano group, a fluorine atom, or a chlorine atom;
• L1 is —O—, —S—, —SO—, —CH(R11)—, —C(═CH2)—, —CO—, 1,1-cyclopropylidene group, or —NR12—;
• R11 is a hydrogen atom, a hydroxy group, a C1-3 alkyl group optionally substituted with 1 to 3 halogen atoms, or a C1-3 alkoxy group optionally substituted with 1 to 2 cyano groups;
• R12 is a hydrogen atom, or a C1-3 alkyl group optionally substituted with 1 to 3 halogen atoms;
• Ar1 is a nitrogen-containing heteroaryl ring optionally substituted with 1 to 3 R2 selected from:
• R2 is independently a halogen atom, a cyano group, or a C1-4 alkyl group optionally substituted with 1 to 3 halogen atoms;
• R3 is a hydrogen atom, a halogen atom, an amino group, a cyano group, a carboxy group, a (C1-3 alkylcarbonyl)amino group, a (C1-6 alkylamino) carbonyl group, a di(C1-3 alkyl)aminocarbonyl group, a (C1-3 alkoxy) carbonyl group, a (C3-8 cycloalkyl)amino group, a (C3-8 heterocycloalkyl)amino group, a C3-8 cycloalkyl group, a 3- to 8-membered heterocycloalkyloxy group, a C3-8 cycloalkyloxy group optionally substituted with 1 to 6 R31, a C1-6 alkyl group optionally substituted with 1 to 6 R31, a C1-6 alkoxy group optionally substituted with 1 to 6 R31, a di(C1-6 alkyl)amino group optionally substituted with 1 to 6 R31, a (C1-6 alkyl)amino group optionally substituted with 1 to 6 R31, a 3- to 8-membered heterocycloalkyl group optionally substituted with 1 to 4 R32, an aryl group optionally substituted with 1 to 4 R32, or a heteroaryl group optionally substituted with 1 to 4 R32;
• R31 is independently a halogen atom, a hydroxy group, a cyclopropylidene group, a C3-8 cycloalkyl group optionally substituted with 1 to 3 halogen atoms, a 3- to 8-membered heterocycloalkyl group, an oxetanylidene group, a C1-4 alkoxy group, or a 3- to 8-membered cycloalkyloxy group;
• R32 is independently a halogen atom, a hydroxy group, an acetylamino group, a C1-3 alkyl group optionally substituted with 1 to 3 halogen atoms, a C1-3 alkoxy group optionally substituted with 1 to 3 halogen atoms, an oxo group, a cyano group, a carboxy group, a (C1-3 alkoxy) carbonyl group, a (C1-3 alkyl) sulfonyl group, a carboxamide group, or a benzyloxy group;
• Ar2 is an aryl ring optionally substituted with 1 to 4 R4, or a heteroaryl ring optionally substituted with 1 to 4 R4;
• R4 is independently a halogen atom, a hydroxy group, a carboxy group, a cyano group, a cyanomethyl group, an amino group, a di(C1-3 alkyl)amino group, a C1-3 alkyl group optionally substituted with 1 to 3 halogen atoms, or C1-3 alkoxy group;
• L2 is a single bond, a C1-6 alkylene group optionally substituted with 1 to 3 R21, a C3-8 cycloalkylene group optionally substituted with 1 to 3 R21, or a 4- to 8-membered heterocycloalkylene group optionally substituted with 1 to 3 R21;
• L2 may be bonded at any position to Ar2 or —NR7R8 which is located at either end thereof;
• One sp3 carbon atom at any position of L2 may be replaced by a structure of —O— or —NR22—;
• R21 is independently a halogen atom, a hydroxy group, an oxo group, a cyano group, a 1,1-cyclopropylidene group, an oxetanylidene group, a carboxy group, a carboxamide group, a C1-6 alkyl group optionally substituted with 1 to 3 halogen atoms, a C3-8 cycloalkyl group, a C1-6 alkoxy group, a (C1-3 alkoxy) C1-3 alkyl group, a (C1-3 alkoxy) C1-3 alkoxy group, a (hydroxy) C1-6 alkyl group, a (carboxy) C1-3 alkyl group, a (carboxy) C1-3 alkoxy group, a (C1-3 alkoxy) carbonyl group, a (C1-3 alkoxycarbonyl) C1-3 alkyl group, a (C1-6 alkylamino) carbonyl group, a di(C1-3 alkyl)aminocarbonyl group, a phenyl group optionally substituted with 1 to 3 halogen atoms, a heteroaryl group optionally substituted with 1 to 3 halogen atoms, or a phenoxy group optionally substituted with 1 to 3 halogen atoms;
• R22 is a hydrogen atom or a C1-3 alkyl group;
• L2 and R7 may be bonded via a single bond, —O—, —S(═O)n—, or —NR23—, to form a 4- to 8-membered ring containing a nitrogen atom to which L2 and R7 are bonded, and the ring is optionally substituted with 1 to 3 halogen atoms or 1 to 2 hydroxy groups;
• n represents an integer from 0 to 2;
• R23 is a hydrogen atom or a C1-3 alkyl group;
• when L2 and R4 are bonded to atoms adjacent to each other on Ar2, they may be bonded via a single-bond or —O— to form a 5- to 8-membered ring together with the atoms of Ar2 to which they are bonded;
• R7 is a hydrogen atom, or C1-3 alkyl group;
• R7 and an atom of Ar2 may be bonded via a single bond to form a 5- to 8-membered ring;
• R8 is a hydrogen atom, a C1-6 alkyl group, an adamantyl group, a C3-6 cycloalkyl group, a cyanomethyl group, an oxetanyl group, a (C1-3 alkylamino) carbonylmethyl group, a di(C1-3 alkyl)aminocarbonylmethyl group, a (C1-3 alkylamino) C1-8 alkyl group, a di(C1-3 alkyl)aminoC1-8 alkyl group, a (hydroxy) C1-8 alkyl group, a (carboxy) C1-3 alkyl group, a (C1-3 alkoxycarbonyl) C1-3 alkyl group, or a (C1-3 alkoxy) C1-3 alkyl group;
• R7 and R8 may be bonded each other via a single bond, —O—, —S(—O)m—, or —NR41— to form a 3- to 8-membered ring, and further, the ring is optionally substituted with an amino group, an oxo group, or a C1-3 alkyl group;
• m represents an integer from 0 to 2;
• R41 is a hydrogen atom or a C1-3 alkyl group.