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US 12,759,968 B2Granted
(S)-3-amino-4-(difluoromethylene)cyclohexene and cyclohexane carboxylic acid and uses thereof as selective inactivators of human ornithine aminotransferase (hOAT)
AssigneeNorthwestern University
InventorsRichard B. Silverman, Wei Zhu
Life of this patent
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Abstract
Disclosed are amino-substituted, halomethylene-substituted cyclohexene carboxylic acid compounds and amino-substituted, halomethylene-substituted cyclohexane carboxylic acid compounds. The disclosed compounds and compositions thereof may be utilized in methods for modulating human ornithine aminotransferase (AO AT) activity, including methods for treating diseases or disorders associated with AO AT activity or expression such as cell proliferative diseases and disorders including cancer.
Claims18
A compound of the following formula or a dissociated form, a non-protonated form, a zwitterion form, or a salt thereof:
- wherein a double bond is optionally present between the α and ζ carbons or wherein a double bond is optionally present between the α and β carbons, and
- wherein each of R1 and R2 is independently selected from F, Cl, Br, and I.
Dependencies are inferred from the claim text.