Microfluidic nucleotide synthesizer
AssigneeLenovo (Singapore) Pte. Ltd.
InventorsHenrique Reis Wisinewski, Bruno Ramos, Sabrina Esperanca Nunes, Ariel Pereira Lima, Bruno Marinaro Verona
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Abstract
A microfluidic system for performing nucleic acid synthesis includes a microfluidic reactor site. A first reactor site valve is coupled upstream of the reactor site. A second reactor site valve is coupled downstream of the reactor site. The system includes a plurality of microfluidic inlets to couple to multiple pressurized reagent containing chambers. A plurality of reagent valves are coupled to individually control a size of droplets of reagent provided by respective pressurized reagent containing chambers. A pressurized gas source is coupled to propel droplets downstream to the microfluidic reactor site.
Claims10
A microfluidic system for synthesizing nucleic acid, the microfluidic system comprising:
- a microfluidic reactor;
- having an upstream side and a downstream side;
- a first microfluidic reactor valve fluidically coupled to the upstream side;
- a second microfluidic reactor valve fluidically coupled to the downstream side;
- a plurality of chambers, each chamber configured to contain a reagent at a pressure above atmospheric pressure;
- a plurality of microfluidic inlets, each microfluidic inlet corresponding to a respective chamber of the plurality of chambers;
- a plurality of reagent valves, each reagent valve controllable to provide a reagent droplet size of a corresponding reagent from the respective chamber;
- a gas source configured to provide a pressurized gas at a pressure above atmospheric pressure and propel reagent droplets to the microfluidic reactor.
Dependencies are inferred from the claim text.