# US 12,758,799 B2 · Wearable ultrasound device and harness for immunomodulation, and uses thereof > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 12,758,799 B2 - Document ID: US12758799B2 - Status: Granted - Kind: B2 - Application number: 18/727,470 - Filed: 2023-01-12 - Published: 2025-03-06 - Granted: 2026-10-13 - Earliest claimed: 2022-01-13 - Assignees: INIA Biosciences, Inc. - Applicants: INIA Biosciences, Inc. - Inventors: Dragana Savic; Shen Ning - Web page: https://patentgrep.com/patent/US12758799B2 ## CPC - A61N 7/00: Ultrasound therapy (lithotripsy A61B17/22, A61B17/225; massage using supersonic vibration A61H23/00 {; using ultrasound for introducing media into the body A61M37/0092}) - A61N 2007/0026: {Stimulation of nerve tissue} - A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B) ## Abstract Provided herein are wearable harnesses for securing and positioning an ultrasound device on a subject. The wearable harnesses can be used to position an ultrasound transducer to a human body. The wearable harnesses may include two adjustable shoulder straps, an adjustable waist strap, a pocket for holding a power pack, and a pocket for holding the transducer. For example, the pocket for holding the transducer may be positioned over the subject's spleen such that the ultrasound transducer may be positioned over the subject's spleen. Provided herein is also a treatment unit to be used to the wearable harness, that includes an ultrasound transducer; and a mechanical lens comprising a plurality of concentric rings and configured to adjust ultrasonic waves emitted by the ultrasound transducer. ## Claims ### Claim 1 A system for securing an ultrasound transducer over a spleen of a subject, the system comprising: a harness comprising: a front portion configured to hold a power pack and configured to be positioned over the subject's chest; a rear portion configured to be positioned over the subject's back, and connected to the front portion by a first shoulder strap and a second shoulder strap, wherein each shoulder strap comprises shoulder strap scales that extend lengthwise along each shoulder strap for adjustment to a set length every time the harness is worn by the subject, wherein a connection region between the first shoulder strap and the rear portion and a connection region between the second shoulder strap and the rear portion comprise an adjustable clasp, wherein the adjustable clasp is configured to connect and disconnect and adjust a connection position between the rear portion and the first shoulder strap or the rear portion and the second shoulder strap, wherein the connection position comprises an overlap region between the first shoulder strap and the rear portion and the second shoulder strap and the rear portion; an adjustable waist strap configured to wrap around a subject's waist and connect the front portion and the rear portion, wherein the adjustable waist strap comprises a waist strap scale that extends lengthwise along the adjustable waist strap for adjustment to a set length every time the harness is worn by the subject; and a transducer securing portion located on the adjustable waist strap and configured to be positioned over a spleen of a subject, wherein the transducer securing portion comprises a two-dimensional transducer securing portion scale that extends length-wise and height-wise along the exterior of the transducer securing portion, wherein the two-dimensional transducer securing portion scale is benchmarked relative to an anatomical landmark of the subject and is configured to align the ultrasound transducer so that the ultrasound transducer is placed in the same position inside the transducer securing portion every time the harness is worn by the subject; and a treatment unit comprising: the ultrasound transducer configured to couple to the transducer securing portion of the harness, wherein the ultrasound transducer is positioned in the same location above the subject's spleen every time the harness is worn. ### Claim 2 (depends on 1) The system of claim 1, wherein the transducer securing portion receives and secures an ultrasound transducer with a mechanism comprising a pop-lock, a magnet, VELCRO®, locking pins, clips, or a key-in arms mechanism. ### Claim 3 (depends on 1) The system of claim 1, further comprising: a mechanical lens positioned between the ultrasound transducer and the subject, wherein the mechanical lens comprising a plurality of concentric rings, and wherein the mechanical lens is configured to adjust ultrasonic waves emitted by the ultrasound transducer to a specific focal distance. ### Claim 4 (depends on 3) The system of claim 3, wherein the focal distance is 0.2-20 cm. ### Claim 5 A harness for positioning an ultrasound transducer to a subject, the harness comprising: a front portion configured to hold a power pack and be positioned over the subject's chest; a rear portion configured to be positioned over the subject's back, and is connected to the front portion by a first shoulder strap and a second shoulder strap, wherein each shoulder strap comprises shoulder strap scales that extend lengthwise along each shoulder strap for adjustment to a set length every time the harness is worn by the subject, wherein a connection region between the first shoulder strap and the rear portion and a connection region between the second shoulder strap and the rear portion comprise an adjustable clasp, wherein the adjustable clasp is configured to connect and disconnect and adjust a connection position between the rear portion and the first shoulder strap or the rear portion and the second shoulder strap, wherein the connection position comprises an overlap region between the first shoulder strap and the rear portion or the second shoulder strap and the rear portion; an adjustable waist strap configured to wrap around a subject's waist and connect the front portion and the rear portion, wherein the adjustable waist strap comprises a waist strap scale that extends lengthwise along the adjustable waist strap for adjustment to a set length every time the harness is worn by the subject; and a transducer securing portion located on the adjustable waist strap and configured to be positioned over a spleen of a subject, wherein the transducer securing portion comprises a two-dimensional transducer securing portion scale that extends length-wise and height-wise along the exterior of the transducer securing portion, wherein the two-dimensional transducer securing portion scale is benchmarked relative to one or more anatomical landmarks of the subject and is configured to align the ultrasound transducer so that the ultrasound transducer is placed in the same position inside the transducer securing portion every time the harness is worn by the subject. ### Claim 6 (depends on 5) The harness of claim 5, wherein the transducer securing portion is configured to receive a treatment unit such that the harness positions the treatment unit over the spleen of the subject. ### Claim 7 (depends on 6) The harness of claim 6, wherein the treatment unit comprises an ultrasound transducer. ### Claim 8 (depends on 7) The harness of claim 7, wherein the treatment unit further comprises a mechanical lens comprising a plurality of concentric rings and configured to adjust ultrasonic waves emitted by the ultrasound transducer. ### Claim 9 (depends on 5) A system for securing an ultrasound transducer over a spleen of a subject, the system comprising: a harness of claim 5; and an ultrasound transducer configured to couple to the transducer securing portion of the harness. ### Claim 10 (depends on 5) A method of using a harness of claim 5 for positioning an ultrasound transducer to a subject, the method comprising: securing a treatment unit to a transducer securing portion of a harness; placing the harness on a subject such that the treatment unit is positioned over a spleen of the subject. ### Claim 11 (depends on 10) The method of claim 10, wherein securing a treatment unit to a transducer securing portion of a harness comprises positioning the treatment unit to the transducer securing portion with the guidance of a two-dimensional transducer securing portion scale on the transducer securing portion so that the treatment unit is placed in the same position inside the transducer securing portion of the harness every time the harness is worn by the subject. ### Claim 12 (depends on 11) The method of claim 11, wherein securing a treatment unit to a transducer securing portion of a harness comprises a mechanism comprising a pop-lock, a magnet, VELCRO®, locking pins, clips, or a key-in arms mechanism. ### Claim 13 (depends on 10) The method of claim 10, wherein the treatment unit comprises an ultrasound transducer. ### Claim 14 (depends on 13) The method of claim 13, wherein the treatment unit comprises a mechanical lens comprising a plurality of concentric rings and configured to adjust ultrasonic waves emitted by the ultrasound transducer.