# US 12,758,796 B2 · Apparatus for radiotherapy and method of operating an apparatus for radiotherapy > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 12,758,796 B2 - Document ID: US12758796B2 - Status: Granted - Kind: B2 - Application number: 18/833,169 - Filed: 2023-01-25 - Published: 2025-04-03 - Granted: 2026-10-13 - Earliest claimed: 2022-01-27 - Assignees: Deutsches Krebsforschungszentrum Stiftung des Offentlichen Rechts - Applicants: Deutsches Krebsforschungszentrum Stiftung Des Offentlichen Rechts - Inventors: Joao Seco; Joao Pedro Oliveira Lourenco; Filipa Baltazar - Web page: https://patentgrep.com/patent/US12758796B2 ## CPC - A61N 5/1048: {Monitoring, verifying, controlling systems and methods} - A61N 5/1031: {using a specific method of dose optimization} - A61N 5/1045: {using a multi-leaf collimator, e.g. for intensity modulated radiation therapy or IMRT} - A61N 5/1084: {for delivering multiple intersecting beams at the same time, e.g. gamma knives} - A61N 2005/1074: {Details of the control system, e.g. user interfaces} - A61N 2005/1087: {Ions; Protons} - A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B) ## Abstract The present disclosure provides an apparatus for radiotherapy. The apparatus includes at least one first radiation source configured to provide one or more ultra-high dose rate charged particle beams; at least one second radiation source configured to provide one or more intensity-modulated beams; and a controller. The controller is configured to control the at least one first radiation source to generate the one or more ultra-high dose rate charged particle beams and control the at least one second radiation source to generate the one or more intensity-modulated beams such that the one or more ultra-high dose rate charged particle beams and the one or more intensity-modulated beams provide a substantially uniform total dose distribution across the target region. ## Claims ### Claim 1 An apparatus for radiotherapy, comprising: at least one first radiation source configured to provide one or more ultra-high dose rate charged particle beams; at least one second radiation source configured to provide one or more intensity-modulated beams; and a controller configured to: control the at least one first radiation source to generate the one or more ultra-high dose rate charged particle beams and control the at least one second radiation source to generate the one or more intensity-modulated beams such that the one or more ultra-high dose rate charged particle beams and the one or more intensity-modulated beams provide a substantially uniform total dose distribution across the target region, wherein the controller is further configured to control the at least one first radiation source to generate the one or more ultra-high dose rate charged particle beams and control the at least one second radiation source to generate the one or more intensity-modulated beams such that a first dose distribution of the one or more ultra-high dose rate charged particle beams and a second dose distribution of the one or more intensity-modulated beams combine in the target region to provide the substantially uniform total dose distribution across the target region, in particular across substantially the entire target region. ### Claim 2 (depends on 1) The apparatus of claim 1, wherein the controller is further configured to: control the at least one first radiation source to generate the one or more ultra-high dose rate charged particle beams such that each ultra-high dose rate charged particle beam of the one or more ultra-high dose rate charged particle beams provides a substantially uniform first dose distribution in a corresponding first region of the target region; and control the at least one second radiation source to generate the one or more intensity-modulated beams such that the one or more intensity-modulated beams provide a substantially uniform second dose distribution in a second region of the target region different from the first region. ### Claim 3 (depends on 2) The apparatus of claim 2, wherein the first region and the second region do not overlap. ### Claim 4 (depends on 2) The apparatus of claim 2, wherein the target region includes the first region, the second region and at least one interface region between the first region and the second region, in particular wherein the controller is further configured to control the at least one first radiation source to generate the one or more ultra-high dose rate charged particle beams and control the at least one second radiation source to generate the one or more intensity-modulated beams such that dose distributions of the one or more ultra-high dose rate charged particle beams and the one or more intensity-modulated beams spatially overlap and add up in the at least one interface region to provide the substantially uniform total dose distribution across the at least one interface region. ### Claim 5 (depends on 1) The apparatus of claim 1, wherein the controller is further configured to control the at least one first radiation source to generate the one or more ultra-high dose rate charged particle beams and control the at least one second radiation source to generate the one or more intensity-modulated beams such that dose distributions of the one or more ultra-high dose rate charged particle beams and the one or more intensity-modulated beams spatially overlap and add up in the target region to provide the substantially uniform total dose distribution across the target region. ### Claim 6 (depends on 5) The apparatus of claim 5, wherein the controller is further configured to: control the at least one first radiation source to generate the one or more ultra-high dose rate charged particle beams such that the dose distribution of the one or more ultra-high dose rate charged particle beams across the target region is non-uniform; and control the at least one second radiation source to generate the one or more intensity-modulated beams such that the dose distribution of the one or more intensity-modulated beams across the target region is non-uniform, wherein the non-uniform dose distributions of the one or more ultra-high dose rate charged particle beams and the one or more intensity-modulated beams add up in the target region to provide the substantially uniform total dose distribution across the target region. ### Claim 7 (depends on 1) The apparatus of claim 1, wherein: the one or more ultra-high dose rate charged particle beams are one or more FLASH beams; and/or the one or more ultra-high dose rate charged particle beams are one or more Single Field Uniform Dose, SFUD, beams; and/or the one or more ultra-high dose rate charged particle beams are modulated to provide a minimum dose of 8, 10 or 12 Gy in one or more volumes of interest and a minimum dose rate of 30, 40 or 50 Gy/s in the one or more volumes of interest, in particular wherein the one or more volumes of interest are spatially separated from the target region. ### Claim 8 (depends on 7) The apparatus of claim 7, wherein the one or more ultra-high dose rate charged particle beams are selected from the group consisting of proton beams, electron beams and ion beams. ### Claim 9 (depends on 6) The apparatus of claim 6, wherein the one or more intensity-modulated beams are selected from the group consisting of photon beams, proton beams, electron beams and ion beams. ### Claim 10 (depends on 9) The apparatus of claim 9, wherein the one or more intensity-modulated beams are Intensity Modulated Proton Therapy (IMPT), beams. ### Claim 11 (depends on 10) The apparatus of claim 10, wherein the one or more ultra-high dose rate charged particle beams and the one or more intensity-modulated beams are pulsed beams that are generated and provided to the target region intermittently. ### Claim 12 (depends on 1) The apparatus of claim 1, wherein the controller is configured to: control the at least one first radiation source such that each ultra-high dose rate charged particle beam passes through a respective volume of interest; and/or control the at least one second radiation source such that the one or more intensity-modulated beams do not pass through a volume of interest. ### Claim 13 A machine-readable storage medium having computer-executable instructions stored, that, when executed, cause one or more processors to perform: control of at least one first radiation source to irradiate a target region with one or more ultra-high dose rate charged particle beams; and control of at least one second radiation source to irradiate the target region with one or more intensity-modulated beams, wherein control of the at least one first radiation source and the at least one second radiation source is performed such that the one or more ultra-high dose rate charged particle beams and the one or more intensity-modulated beams provide a substantially uniform total dose distribution across the target region, and a controller is further configured to control the at least one first radiation source to generate the one or more ultra-high dose rate charged particle beams and control the at least one second radiation source to generate the one or more intensity-modulated beams such that a first dose distribution of the one or more ultra-high dose rate charged particle beams and a second dose distribution of the one or more intensity-modulated beams combine in the target region to provide the substantially uniform total dose distribution across the target region, in particular across substantially the entire target region. ### Claim 14 (depends on 1, 13) The machine-readable storage medium of claim 13 and having computer-executable instructions stored, that, when executed, cause the one or more processors to perform the functionalities of the apparatus according to claim 1.