Personalized ultra-fractionated stereotactic adaptive radiotherapy
AssigneeBoard of Regents, The University of Texas System
InventorsRobert Timmerman, Debabrata Saha, Michael D. Story, Hak Choy, Steve Bin Jiang
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Abstract
In one aspect, the present disclosure relates to a method of adaptive treatment of a subject with a tumor. The method may include administering a first pulse dose of radiation to a tumor within a subject; administering a second pulse dose of radiation to the tumor, wherein the second pulse dose is administered after an observation period, the observation period having a duration of at least 7 days; and concurrently treating the subject with an immunotherapy.
Claims19
A method of adaptive treatment of a subject with a tumor comprising:
- administering a first pulse dose of radiation to the tumor within the subject;
- in response to administering the first pulse dose, determining, using a machine learning model, at least a duration of an observation period;
- administering a second pulse dose of radiation to the tumor, wherein the second pulse dose is administered after the observation period, the observation period having the duration of at least 7 days;
- and
- concurrently treating the subject with an immunotherapy.
A method of adaptive treatment of a subject with a tumor comprising:
- administering a first pulse dose of radiation to the tumor within the subject;
- concurrently treating the subject with an immunotherapy;
- measuring biologic features of at least one of the subject or the tumor;
- applying at least one medical imaging technique to at least one of the subject or the tumor;
- analyzing results of the at least one medical imaging technique and the biologic features with a machine learning model;
- determining, based on the analysis with the machine learning model, at least a duration between the first pulse dose and a second pulse dose;
- and
- administering the second pulse dose, wherein the second pulse dose is administered at least 7 days after the first pulse dose.
A method of adaptive treatment of a subject with a tumor comprising:
- administering a first pulse dose of radiation to the tumor within the subject;
- measuring biologic features of at least one of the subject or the tumor;
- applying at least one medical imaging technique to at least one of the subject or the tumor;
- analyzing results of the at least one medical imaging technique and the biologic features with a machine learning model;
- determining, based on the analysis with the machine learning model, at least a duration between the first pulse dose and a second pulse dose;
- and
- administering the second pulse dose, wherein the second pulse dose is administered at least 7 days after the first pulse dose.
Dependencies are inferred from the claim text.