Local field potential (LFP) sensing for neurostimulation control
AssigneeMedtronic, Inc.
InventorsDavid A. Dinsmoor, Leonid M. Litvak, Juan G. Hincapie
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Abstract
A system may be configured to sense local field potentials (LFPs) from electrodes placed in epidural space near the spine of a patient. The system may be configured to analyze the sensed LFPs and determine a change in a state of the patient, such as a physiological state of the patient. The system may use such analysis to update and/or suggest parameters for delivery of electrical stimulation therapy. The system may further be configured to analyze LFPs in a frequency domain by applying a wavelet transform or other transform to sensed LFPs.
Claims21
A system comprising:
- a memory configured to receive and store a local field potential (LFP) signal received from one or more electrodes disposed in an epidural space adjacent at least one of a cervical, thoracic, or lumbar region of a spinal cord of a patient;
- and
- processing circuitry configured to:
- determine that an evoked compound action potential (ECAP) signal fluctuates less than a threshold amount during a period of time;
- obtain the LFP signal sensed during the period of time;
- apply a frequency transform to the LFP signal to create a frequency transformed LFP signal;
- and
- determine a change in a physiological state of the patient from the frequency transformed LFP signal.
A method comprising:
- determining, by processing circuitry, that an evoked compound action potential (ECAP) signal fluctuates less than a threshold amount during a period of time;
- obtaining, by the processing circuitry, a local field potential (LFP) signal sensed during the period of time, wherein the LFP signal is received from one or more electrodes disposed in an epidural space adjacent at least one of a cervical, thoracic, or lumbar region of a spinal cord of a patient;
- applying, by the processing circuitry, a frequency transform to the LFP signal to create a frequency transformed LFP signal;
- and
- determining, by the processing circuitry, a change in a physiological state of the patient from the frequency transformed LFP signal.
A non-transitory computer-readable medium storing instructions that, when executed, causes one or more processors to:
- determine that an evoked compound action potential (ECAP) signal fluctuates less than a threshold amount during a period of time;
- obtain a local field potential (LFP) signal sensed during the period of time, wherein the LFP signal is received from one or more electrodes disposed in an epidural space adjacent at least one of a cervical, thoracic, or lumbar region of a spinal cord of a patient;
- apply a frequency transform to the LFP signal to create a frequency transformed LFP signal;
- and
- determine a change in a physiological state of the patient from the frequency transformed LFP signal.
Dependencies are inferred from the claim text.