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OwnerArnold W. Thornton, Dennis Dong-won Kim +3inventors
InventorsArnold W. Thornton, Dennis Dong-won Kim, Mark B. Knudson, Katherine S. Tweden, Richard R. Wilson
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Various methods and apparatus for treating a condition associated with impaired glucose regulation in a subject comprising in one embodiment, applying a neural conduction block to a target nerve at a blocking site with the neural conduction block selected to at least partially block nerve pulses. In another embodiment, combinations of down-regulating and or up-regulating with or without pharmaceutical agents are used to treat impaired glucose regulation. In other embodiments, up-regulation or down-regulation of various nerves, such as the vagus and its branches, and the splanchnic is used to modify the production of GLP-1 and GIP, thereby controlling glucose levels. In yet further embodiments, combinations of down-regulating and or up-regulating with or without pharmaceutical agents are used to modify the production of GLP-1 and GIP, to treat impaired glucose regulation.
A method of regulating glucose levels in a patient, the method comprising:
A method for treating a patient with impaired glucose regulation, comprising applying an first electrical signal to a first target nerve or organ of the subject, with said first electrical signal selected to down-regulate neural activity on the first nerve or organ and to restore neural activity on the first nerve or organ upon discontinuance of said first electrical signal;
Dependencies are inferred from the claim text.