# US 12,758,711 B2 · Integrated package for administration of lyophilized medicines

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- Number: US 12,758,711 B2
- Document ID: US12758711B2
- Status: Granted
- Kind: B2
- Application number: 18/076,777
- Filed: 2022-12-07
- Published: 2023-06-08
- Granted: 2026-10-13
- Earliest claimed: 2021-12-07
- Applicants: Andrew John Clapham; Charles Heldebrant
- Inventors: Andrew John Clapham; Charles Heldebrant
- Web page: https://patentgrep.com/patent/US12758711B2

## CPC

- A61M 5/19: having more than one chamber
- A61M 5/282: {by compression of deformable ampoule or carpule wall}
- A61M 2039/0027: {for mixing several substances from different containers}
- A61M 2039/0036: {characterised by a septum having particular features, e.g. having venting channels or being made from antimicrobial or self-lubricating elastomer}
- A61M 2039/2446: {Flexible disc}
- A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)}

## Abstract

An auto-disable prefillable integrated package apparatus includes a first chamber, a second chamber, a connection configured to form a communicable channel between the first chamber and the second chamber, a frangible membrane configured to form a rupturable barrier within the connector that separates the first chamber and the second chamber, and a hub configured to be communicably coupled to the second chamber.

## Claims

### Claim 1

An auto-disable prefillable integrated package apparatus, comprising:
a top half having a top boundary geometry; and
a lower half having a lower boundary geometry similar to the top boundary geometry and configured to couple to the top half;
wherein the top half and the lower half are configured such that the top half and the lower half when coupled form the auto-disable prefillable integrated package comprising;
a first chamber;
a second chamber;
a connector configured to form a communicable channel between the first chamber and the second chamber;
a frangible membrane configured to form a rupturable barrier within the connector that separates the first chamber and the second chamber;
a hub configured to be communicably coupled to the second chamber; and
a bonded periphery coupled to the hub and surrounding the first chamber and the second chamber;
wherein the bonded periphery forms an outer boundary of the auto-disable prefillable integrated package along a perimeter of the auto-disable prefillable integrated package defined by the top boundary geometry coupled to the lower boundary geometry.

### Claim 2 (depends on 1)

The auto-disable prefillable integrated package apparatus of claim 1, wherein the second chamber comprises a compressible inner volume.

### Claim 3 (depends on 1)

The auto-disable prefillable integrated package apparatus of claim 1, further comprising a valve configured to prevent fluid flow from the second chamber into the first chamber via the connector.

### Claim 4 (depends on 3)

The auto-disable prefillable integrated package apparatus of claim 3, wherein the valve comprises a disc valve.

### Claim 5 (depends on 1)

The auto-disable prefillable integrated package apparatus of claim 1, further comprising a needle assembly configured to be communicatively coupled to the hub.

### Claim 6 (depends on 1)

The auto-disable prefillable integrated package apparatus of claim 1, wherein the outer boundary of the auto-disable prefillable integrated package apparatus is configured in a rectangular geometry.

### Claim 7 (depends on 1)

The auto-disable prefillable integrated package apparatus of claim 1, wherein the frangible membrane is configured to rupture when a mechanical force above a rupture threshold is applied by a user to the connector.

### Claim 8 (depends on 1)

The auto-disable prefillable integrated package apparatus of claim 1, wherein the hub comprises a port.

### Claim 9 (depends on 1)

The auto-disable prefillable integrated package apparatus of claim 1, wherein the frangible membrane comprises a polymer compound.