# US 12,758,709 B2 · Drug cartridge, drug delivery device, and methods for preparing thereof

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- Number: US 12,758,709 B2
- Document ID: US12758709B2
- Status: Granted
- Kind: B2
- Application number: 18/569,136
- Filed: 2022-06-13
- Published: 2024-11-28
- Granted: 2026-10-13
- Earliest claimed: 2021-06-11
- Assignees: Bristol-Myers Squibb Company
- Applicants: Bristol-Myers Squibb Company
- Inventors: Martin John McLoughlin; Mark Steven Howansky; George Tyler Currier; Peter William Heyman; Yuhong Wu; Erinc Sahin; Shreya Shashank Kulkarni; Ankur Sagar Kulshrestha; Xiaodong Chen; Haresh Tukaram More; Krishna Jagdish Patel; John Christian Knutsen; James William Kidner Bradford; Simon Francis Brereton; Timothy Donald Barrow-Williams; Christopher William Rosier; Jeffrey Nicholas Philippson; Ryan Anthony McGinley; Francesco Giuseppe Sasia; Holly Charlotte Palmer; Tomas Alexander Ogg Correa; Carys Eleri Lee; Paul Antony Merritt; Terence Zhi Seow
- Web page: https://patentgrep.com/patent/US12758709B2

## CPC

- A61M 5/16827: {controlling delivery of multiple fluids, e.g. sequencing, mixing or via separate flow-paths (infusion of multiple fluids without using a controller A61M5/1407)}
- A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)}

## Abstract

In one aspect, a drug delivery device is provided herein including: a monolithic body having a plurality of fluid ducts and at least one outlet duct formed therein; a plurality of drug cartridges attached to the body, the drug cartridges each including a reservoir for accommodating at least one drug wherein, the plurality of fluid ducts is arranged to convey the drugs from the drug cartridges to the at least one outlet duct; and, a needle support spaced from the body, the needle support including a needle configured for insertion into a patient for drug delivery, the needle support including adhesive for releasable securement to a patient, wherein, the needle support is connected to the body by a flexible tether through which passes at least one fluid passageway formed to convey drug from the at least one outlet duct to the needle.

## Claims

### Claim 1

A drug delivery device comprising:
a body having a plurality of fluid ducts and at least one outlet duct formed therein; and,
a plurality of drug cartridges attached to the body, the drug cartridges each including a reservoir for accommodating at least one drug,
wherein, a first of the drug cartridges includes a fluid outlet,
wherein, a first of the fluid ducts, is aligned to extend from the fluid outlet,
wherein, an adjustable seal, formed by a sealing sheet joined to a sealing surface, selectively seals the fluid outlet, the seal being adjustable from a first state, where the fluid outlet is sealed, to a second state, where the fluid outlet is not sealed,
wherein the sealing sheet is secured to a shiftable sealing element, and, wherein displacement of the shiftable sealing element causes delamination of the sealing sheet from the sealing surface and results in adjustment of the seal from the first state to the second state.

### Claim 2 (depends on 1)

The drug delivery device of claim 1, wherein the shiftable sealing element includes multiple open passageways which come into alignment with the fluid outlet with the seal being in the second state.

### Claim 3 (depends on 2)

The drug delivery device of claim 2, wherein the open passageways are provided at multiple radial locations about the shiftable sealing element.

### Claim 4 (depends on 1)

The drug delivery device of claim 1, wherein the shiftable sealing element is displaced in response to pressure being applied thereto.

### Claim 5 (depends on 1)

The drug delivery device of claim 1, wherein the shiftable sealing element is initially seated in a well, the sealing surface being located about the well.

### Claim 6 (depends on 5)

The drug delivery device of claim 5, wherein the shiftable sealing element is displaced to protrude from the well in causing the sealing sheet to delaminate from the sealing surface.

### Claim 7 (depends on 5)

The drug delivery device of claim 5, wherein the fluid outlet includes a divergent portion leading into the well and a convergent portion leading out of the well.

### Claim 8 (depends on 1)

The drug delivery device of claim 1, wherein the sealing sheet is a thermoformable film.