Medical infusion pump system for the delivery of an insulin compound
AssigneeArecor Limited
InventorsJan Jezek, David Gerring, Sarah Howell, Leon Zakrzewski
Life of this patent
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Abstract
Provided herein is a medical infusion pump system that contains a pump and a reservoir containing an aqueous liquid pharmaceutical composition that is delivered to a subject by the pump and that contains an insulin compound at a concentration of 400 U/mL or more, ionic zinc and a non-ionic surfactant, and wherein the pump delivers the composition in pulses wherein the volume of the pulse is 0.5 μL or less.
Claims48
A medical infusion pump system comprising a pump and a reservoir comprising an aqueous liquid pharmaceutical composition, wherein the pump is capable of delivering the pharmaceutical composition to a mammal,
- wherein the pharmaceutical composition comprises (i) an insulin compound selected from the group consisting of insulin lispro, insulin glulisine, insulin aspart, insulin glargine, and recombinant human insulin, at a concentration of 400 to 1000 U/mL, (ii) ionic zinc at a concentration of 0.05-1%, by weight of zinc based on the weight of the insulin compound in the composition, (iii) an alkyl glycoside at a concentration of 10-200 μg/mL, (iv) citrate at a concentration of 30 to 60 mM (v) and wherein the composition comprises <7 mM chloride ions, and
- wherein the pump is capable of delivering the pharmaceutical composition in pulses, at a pulse volume of 0.005 to 0.5 μL.
Dependencies are inferred from the claim text.